|
Abnormality of cardiovascular system morphology
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Abnormality of the corticospinal tract
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of the voice
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Acute lymphocytic leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Expression of the DCC gene was reduced or absent in 10 of 39 (26%) patients with acute myelogenous leukemia (AML), three of 14 (29%) patients with acute lymphocytic leukemia (ALL), seven of 33 (21%) patients with chronic myelogenous leukemia (CML), three of 39 (8%) patients with myelodysplastic syndromes (MDS), and five of nine (56%) patients with overt leukemia progressed from MDS.
|
7696919 |
1994 |
|
Acute lymphocytic leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Moreover, in one ALL patient with absent DCC expression at diagnosis, its expression became normal after performing chemotherapy and achieving remission.
|
8338956 |
1993 |
|
Acute myocardial infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to investigate the effect of aerobic exercise on the expression of neitrin-1,DCC receptor and myocardial fibrosis in rats with acute myocardial infarction.
|
30789913 |
2019 |
|
Adenocarcinoma
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Resected pancreatic ductal and ampullary adenocarcinomas (n = 50) were analyzed for loss of heterozygosity (LOH) at 15 markers including 5q(APC), 6q(TBSP2), 9p(p16), 10q(PTEN), 12q(MDM2), 17p(TP53), and 18q(DCC/SMAD4).
|
18677542 |
2008 |
|
Adenocarcinoma
|
0.080 |
Biomarker
|
group |
BEFREE |
These results suggest that LOH at the sites of the DCC, adenomatous polyposis coli (APC), and TP53 tumor suppressor genes occur before the development of adenocarcinoma in Barrett's esophagus, and so merit further study as potential biomarkers of neoplastic progression in patients with Barrett's esophagus undergoing endoscopic and histological surveillance.
|
10667431 |
1999 |
|
Adenocarcinoma
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Progression to the adenocarcinoma phenotype was shown to involve a specific chromosome 1 rearrangement, loss of both normal copies of chromosome 18 (although DCC gene sequences were retained), loss of the remaining wild type allele of k-ras resulting in homozygosity for the k-ras codon 12 mutation and increased cellular p53 protein as detected by SDS-PAGE Western blotting.
|
8414507 |
1993 |
|
Adenocarcinoma
|
0.080 |
Biomarker
|
group |
BEFREE |
In addition to the p53 gene on 17p and the DCC gene on 18q, which are known to be frequently deleted in differentiated adenocarcinomas of the stomach, other unknown tumour suppressor genes on the above-mentioned chromosomes may also be inactivated.
|
9014856 |
1996 |
|
Adenocarcinoma
|
0.080 |
GeneticVariation
|
group |
BEFREE |
LOH on chromosome 18q (DCC locus) and LOH of the bcl-2 gene also are common events of well-differentiated adenocarcinoma.
|
8440743 |
1993 |
|
Adenocarcinoma
|
0.080 |
GeneticVariation
|
group |
BEFREE |
We examined 72 esophageal tumors (46 squamous cell carcinomas and 26 adenocarcinomas) for loss of heterozygosity at the p53, Rb, APC, MCC, and DCC loci.
|
1423299 |
1992 |
|
Adenocarcinoma
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Four of the five tumors with associated adenocarcinoma showed LOH of the DCC gene; in three of these four tumors, the PDNC and adenomatous components showed LOH of the same allele.
|
9326914 |
1997 |
|
Adenocarcinoma
|
0.080 |
Biomarker
|
group |
BEFREE |
The presence of chromosome 18q loss and DPC4 mutations in appendiceal adenocarcinomas suggests involvement of DPC4 and nearby genes on chromosome 18q (DCC and/or JV-18) in the pathogenesis of appendiceal adenocarcinomas.
|
14647445 |
2004 |
|
Adenocarcinoma of large intestine
|
0.310 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Adenocarcinoma of large intestine
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Loss of heterozygosity (LOH) of 18q, where the gene is located, and absence of DCC protein expression have been associated with worse prognosis in certain subgroups of patients with colorectal adenocarcinoma.
|
12901278 |
2003 |
|
Adenocarcinoma of pancreas
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that loss of DCC gene expression is an important factor in the development or progress of pancreatic adenocarcinoma and may be linked to the differentiated phenotype of the pancreatic tumor cell.
|
1314700 |
1992 |
|
Adenocarcinoma of pancreas
|
0.020 |
Biomarker
|
disease |
BEFREE |
Cholangiocarcinoma involving the distal common bile duct (distal cholangiocarcinoma [DCC]) is a periampullary neoplasm that is less common than, but often difficult to distinguish from, pancreatic adenocarcinoma (PDA).
|
24679424 |
2014 |
|
Adenocarcinoma of rectum
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Recognized molecular changes critical for rectal carcinogenesis including APC and DCC loss of heterozygosity, K-ras mutations, and microsatellite instability are not useful as indicators of tumor regression following chemoradiation for rectal carcinoma.
|
19304403 |
2009 |
|
Adenoma
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Early loss of deleted in colorectal carcinoma gene transcript detected in a group of benign colon adenomas.
|
12432238 |
2003 |
|
Adenoma
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Loss of 1p(33-35) region was shown to be the most common chromosome 1 abnormality and loss of heterozygosity (LOH) of the DCC gene and/or adjacent sequences was detected in all adenoma derived cells as well as the carcinoma cell lines.
|
8414507 |
1993 |
|
Adenoma
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Loss of DCC expression is rare in borderline tumors and adenomas, suggesting that inactivation of DCC may be directly involved in malignant transformation.
|
12770737 |
2003 |
|
Adenoma
|
0.050 |
AlteredExpression
|
group |
LHGDN |
Early loss of deleted in colorectal carcinoma gene transcript detected in a group of benign colon adenomas.
|
12432238 |
2003 |
|
Adenoma
|
0.050 |
GeneticVariation
|
group |
BEFREE |
One is the chromosomal instability pathway (adenoma-carcinoma sequence), which is characterized by allelic losses on chromosome 5q (APC), 17p (p53), and 18q (DCC/SMAD4), and the other is a pathway that involves microsatellite instability.
|
16699851 |
2006 |
|
Adenoma
|
0.050 |
GeneticVariation
|
group |
BEFREE |
In the normal tissue, codon 201Gly of the DCC gene was more frequently observed in patients with flat-type adenoma with low-grade dysplasia (67%) than in those with polypoid-type adenoma with low-grade dysplasia (18%) or in normal controls (17%, P < 0.05, chi2 test).
|
9440618 |
1997 |