|
Liver Cirrhosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among patients with cirrhosis (n = 2157), DAA therapy was associated with a 72% and a 62% lower incidence of HCC (hazard ratio [HR], 0.28; 95% confidence interval [CI], 0.15-0.52) and DCC (HR, 0.38; 95% CI, 0.26-0.56).
|
30289989 |
2019 |
|
Myocardial Infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Aerobic exercise increased levels of serum netrin-1, myocardial netrin-1, and the DCC receptor and reduced the expression of myocardial MMP2 and MMP9 proteins, to improve the degree of fibrosis following myocardial infarction in rats.
|
30789913 |
2019 |
|
Neuralgia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
<b>Conclusions:</b> Through activation of μ-opioid receptors, treatment with EA reduces the expression level of DCC and Netrin-1 and changes a growth-permissive environment in spinal dorsal horn into an inhibitory environment by increasing UNC5H2, thus decreasing RTX-caused primary afferent nerve sprouting in the spinal dorsal horn and neuropathic pain.
|
31118749 |
2019 |
|
Depressive Symptoms
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
No SNP was individually significant in either GWAS, but gene-based tests identified six genes associated with depressive symptoms in UK Biobank (DCC, ACSS3, DRD2, STAG1, FOXP2 and KYNU; p < 2.77 × 10<sup>-6</sup>).
|
30718454 |
2019 |
|
Acute myocardial infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to investigate the effect of aerobic exercise on the expression of neitrin-1,DCC receptor and myocardial fibrosis in rats with acute myocardial infarction.
|
30789913 |
2019 |
|
Adult Meningioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The DCC netrin 1 receptor (DCC) is a candidate gene for early meningioma progression.
|
31083655 |
2019 |
|
Decompensated cirrhosis of liver
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Approved treatment for hepatitis C virus (HCV) with all-oral direct-acting antivirals (DAA) therapy is now entering into its fourth year; however, little has been reported on the real-world clinical (decompensated cirrhosis [DCC] and hepatocellular carcinoma [HCC]) and economic outcomes.
|
30289989 |
2019 |
|
Cirrhosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among patients with cirrhosis (n = 2157), DAA therapy was associated with a 72% and a 62% lower incidence of HCC (hazard ratio [HR], 0.28; 95% confidence interval [CI], 0.15-0.52) and DCC (HR, 0.38; 95% CI, 0.26-0.56).
|
30289989 |
2019 |
|
Meningioma, benign, no ICD-O subtype
|
0.010 |
Biomarker
|
disease |
BEFREE |
The DCC netrin 1 receptor (DCC) is a candidate gene for early meningioma progression.
|
31083655 |
2019 |
|
Biliary Tract Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Outcomes for the four anatomical subtypes of biliary tract carcinoma (BTC) - intrahepatic, perihilar and distal cholangiocarcinoma (ICC, PHCC, DCC) and gallbladder carcinoma (GBC) - are often combined.
|
31494056 |
2019 |
|
Dehydration
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We have immobilized poly(ethylene glycol) (PEG) on the surfaces of poly(lactic-co-glycolic acid) (PLGA) nanoparticles by two different chemical methods, i.e., SOCl2 halogenate-alcoholysis and DCC dehydration.
|
30283943 |
2018 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Whether or not NT-1/DCC and VEGF interact in regulating angiogenesis of OA cartilage is not known.
|
29843768 |
2018 |
|
Involuntary Movements
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Humans with heterozygous mutations in the axon guidance receptor DCC display congenital mirror movements (MMs), which are involuntary movements of body parts, such as fingers, on one side of the body that mirror voluntary movement of the opposite side.
|
28691197 |
2018 |
|
Pyogenic Arthritis, Pyoderma Gangrenosum and Acne
|
0.010 |
Biomarker
|
disease |
BEFREE |
The DCC family receptor Frazzled (Fra) signals chemoattraction and promotes midline crossing in response to its ligand Netrin.
|
29617376 |
2018 |
|
mucosal melanoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Of clinical relevance, presence of DCC mutations was significantly associated with poorer overall survival in MM (log-rank test, p = 0.02).
|
30373548 |
2018 |
|
Atrial Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ninety-six consecutive patients with persistent AF were randomized after PVI to either direct current synchronized cardioversion (DCC group, n = 48) or 1 mg of intravenous ibutilide (ibutilide group, n = 48) followed by no further intervention if AF converted to sinus rhythm (SR) within 30 minutes (ibutilide conversion subgroup) or by complex fractionated atrial electrogram (CFAE) ablation until SR recovery or complete CFAE elimination (ibutilide nonconversion subgroup).
|
28501100 |
2017 |
|
Myasthenia Gravis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Antibodies against Netrin-1 receptors (DCC and UNC5a) and Caspr2 often coexist and associate with thymoma in patients with neuromyotonia and myasthenia gravis.
|
28251919 |
2017 |
|
Thymoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Antibodies against Netrin-1 receptors (DCC and UNC5a) and Caspr2 often coexist and associate with thymoma in patients with neuromyotonia and myasthenia gravis.
|
28251919 |
2017 |
|
Isaacs syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Antibodies against Netrin-1 receptors (DCC and UNC5a) and Caspr2 often coexist and associate with thymoma in patients with neuromyotonia and myasthenia gravis.
|
28251919 |
2017 |
|
Sialic Acid Storage Disease, Finnish Type (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
The selected key symptoms could be simple DH and SD syndromes diagnostic elements applied in clinical directly.(Registration N0.: ChiCTR-DCC-10000759).
|
27225292 |
2017 |
|
Glioma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In a subject with Hodgkin lymphoma and subsequent low-grade glioma, we identified t(5;18)(q35.1;q21.2), disrupting both SLIT3 and DCC, genes previously implicated in both glioma and lymphoma.
|
25569436 |
2015 |
|
Hodgkin Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In a subject with Hodgkin lymphoma and subsequent low-grade glioma, we identified t(5;18)(q35.1;q21.2), disrupting both SLIT3 and DCC, genes previously implicated in both glioma and lymphoma.
|
25569436 |
2015 |
|
Monoclonal Gammopathy of Undetermined Significance
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In patient-derived samples from 30 MM and 8 monoclonal gammopathy of undetermined significance (MGUS) patients, wt.DCC was expressed in 53% of MM, but not in MGUS, while 23% of MM and 75% of MGUS expressed only sv.DCC.
|
26390996 |
2015 |
|
Adult Hodgkin Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In a subject with Hodgkin lymphoma and subsequent low-grade glioma, we identified t(5;18)(q35.1;q21.2), disrupting both SLIT3 and DCC, genes previously implicated in both glioma and lymphoma.
|
25569436 |
2015 |
|
Childhood Hodgkin Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In a subject with Hodgkin lymphoma and subsequent low-grade glioma, we identified t(5;18)(q35.1;q21.2), disrupting both SLIT3 and DCC, genes previously implicated in both glioma and lymphoma.
|
25569436 |
2015 |