|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Gastroesophageal reflux disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Preoperatively the median DCI (299 ES vs. 1523.5 MSA vs. 1132 NF, p = 0.001), HH size (0.5 cm ES vs. 1 cm MSA vs. 2 cm NF, p = 0.001) and presence of GERD-related symptoms differed significantly between the groups.
|
31844179 |
2019 |
|
Gastroesophageal reflux disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
In the preoperative findings on MII-pH, the RE+ group demonstrated significantly longer acid reflux time (4.7 vs. 1.3%, p = 0.005), while in the HRM findings, the RE- group demonstrated a significantly longer abdominal esophagus (0 vs. 0.4 cm, p = 0.049) and maintained esophageal body motor function (DCI: 1054 vs. 1407 mmHg s cm, p = 0.021, Intact peristalsis ratio: 90 vs. 100%, p = 0.037).
|
30225739 |
2018 |
|
Esophageal Achalasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Increased MRS DCI was seen in 53% type 2 achalasia, 92% type 3 achalasia, 10% EGJOO, 22% jackhammer, and 18% DES.
|
30805798 |
2019 |
|
Hydrocephalus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Multivariable logistic regression analysis revealed that death or functional dependence (defined as an mRS score of 4 to 6) at hospital discharge was independently associated with sepsis (OR 3.4, 95% CI 1.16-9.96, p = 0.026) even after controlling for World Federation of Neurological Surgeons (WFNS) Scale (OR 4.66, 95% CI 1.69-12.88, p = 0.003), hydrocephalus (OR 4.55, 95% CI 1.61-12.85, p = 0.004) and DCI (OR 3.86, 95% CI 1.39-10.74, p = 0.01).
|
31432283 |
2019 |
|
Septicemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Multivariable logistic regression analysis revealed that death or functional dependence (defined as an mRS score of 4 to 6) at hospital discharge was independently associated with sepsis (OR 3.4, 95% CI 1.16-9.96, p = 0.026) even after controlling for World Federation of Neurological Surgeons (WFNS) Scale (OR 4.66, 95% CI 1.69-12.88, p = 0.003), hydrocephalus (OR 4.55, 95% CI 1.61-12.85, p = 0.004) and DCI (OR 3.86, 95% CI 1.39-10.74, p = 0.01).
|
31432283 |
2019 |
|
Sepsis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Multivariable logistic regression analysis revealed that death or functional dependence (defined as an mRS score of 4 to 6) at hospital discharge was independently associated with sepsis (OR 3.4, 95% CI 1.16-9.96, p = 0.026) even after controlling for World Federation of Neurological Surgeons (WFNS) Scale (OR 4.66, 95% CI 1.69-12.88, p = 0.003), hydrocephalus (OR 4.55, 95% CI 1.61-12.85, p = 0.004) and DCI (OR 3.86, 95% CI 1.39-10.74, p = 0.01).
|
31432283 |
2019 |
|
Achalasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Increased MRS DCI was seen in 53% type 2 achalasia, 92% type 3 achalasia, 10% EGJOO, 22% jackhammer, and 18% DES.
|
30805798 |
2019 |
|
Hiatal Hernia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Preoperatively the median DCI (299 ES vs. 1523.5 MSA vs. 1132 NF, p = 0.001), HH size (0.5 cm ES vs. 1 cm MSA vs. 2 cm NF, p = 0.001) and presence of GERD-related symptoms differed significantly between the groups.
|
31844179 |
2019 |
|
Peptic Esophagitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, for both groups, the total length of the lower esophageal sphincter (LES) (RE+ group: 2.7 vs. 3.2 cm, p = 0.001, RE- group: 3.0 vs. 3.4 cm, p = 0.003) and the total length of the abdominal esophagus (RE+ group: 0 vs. 1.6 cm, p < 0.001, RE- group: 0 vs. 1.8 cm, p = 0.001) were significantly extended following surgery; however, no change was observed in DCI before and after surgery.
|
30225739 |
2018 |
|
Heartburn
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In the preoperative findings on MII-pH, the RE+ group demonstrated significantly longer acid reflux time (4.7 vs. 1.3%, p = 0.005), while in the HRM findings, the RE- group demonstrated a significantly longer abdominal esophagus (0 vs. 0.4 cm, p = 0.049) and maintained esophageal body motor function (DCI: 1054 vs. 1407 mmHg s cm, p = 0.021, Intact peristalsis ratio: 90 vs. 100%, p = 0.037).
|
30225739 |
2018 |
|
Gastro-esophageal reflux disease with esophagitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, for both groups, the total length of the lower esophageal sphincter (LES) (RE+ group: 2.7 vs. 3.2 cm, p = 0.001, RE- group: 3.0 vs. 3.4 cm, p = 0.003) and the total length of the abdominal esophagus (RE+ group: 0 vs. 1.6 cm, p < 0.001, RE- group: 0 vs. 1.8 cm, p = 0.001) were significantly extended following surgery; however, no change was observed in DCI before and after surgery.
|
30225739 |
2018 |
|
Deglutition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The symptom chest pain was not associated with any of the manometric findings, whereas dysphagia was associated with the DCI of the hypercontractile swallows and with intrabolus pressure.
|
27753176 |
2017 |
|
Polycystic Ovary Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on the published results, both MI and DCI represent potential valid therapeutic approaches for the treatment of insulin resistance and its associated metabolic and reproductive disorders, such as those occurring in women affected by PCOS.
|
28642705 |
2017 |
|
Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The patients were divided into cerebral vasospasm group (CVS group) (n = 37) and no convulsion group (non-CVS group) (n = 46); delayed cerebral ischemia group (DCI group) (n = 31) and non-delayed cerebral ischemia group (non-DCI group) (n = 52).
|
29077161 |
2017 |
|
Subarachnoid Hemorrhage
|
0.010 |
Biomarker
|
disease |
BEFREE |
No significant difference between blood type and the reviewed variables for SAH outcome were identified: World Federation of Neurosurgical Societies admission status (odds ratio, 1.12; 95% confidence interval [CI], 0.7-1.6; P = 0.56); SAH-associated intracerebral hemorrhage (odds ratio, 0.81; 95% CI, 0.5-1.3; P = 0.36); cerebral vasospasm (odds ratio, 1.08; 95% CI, 0.7-1.6; P = 0.71); DCI (odds ratio, 1.23; 95% CI, 0.8-1.8; P = 0.30); Fisher grade (odds ratio, 1.13; 95% CI, 0.7-1.6; P = 0.19).
|
27777156 |
2017 |
|
Convulsions
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The patients were divided into cerebral vasospasm group (CVS group) (n = 37) and no convulsion group (non-CVS group) (n = 46); delayed cerebral ischemia group (DCI group) (n = 31) and non-delayed cerebral ischemia group (non-DCI group) (n = 52).
|
29077161 |
2017 |
|
Noninfiltrating Intraductal Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To determine whether synchronously diagnosed ipsilateral DCI and IDCs have modal populations with distinct repertoires of gene copy number aberrations and mutations in common oncogenes, matched frozen samples of DCIS and IDC were retrieved from 13 patients and subjected to microarray-based comparative genomic hybridization (aCGH) and Sequenom MassARRAY (Oncocarta v 1.0 panel).
|
22252965 |
2012 |
|
Cardiomyopathy, Familial Idiopathic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although the genomic profiles of matched DCI and IDCs were similar, in three of 13 matched pairs amplification of distinct loci (ie 1q41, 2q24.2, 6q22.31, 7q11.21, 8q21.2 and 9p13.3) was either restricted to, or more prevalent in, the modal population of cancer cells of one of the components.
|
22252965 |
2012 |