DCK, deoxycytidine kinase, 1633

N. diseases: 102; N. variants: 6
Disease: Acute monocytic leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia 		0.030 Biomarker disease BEFREE Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML. 27808171 2016
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia 		0.030 AlteredExpression disease BEFREE The mRNA expression for dCK, dGK and 5'-NT (expressed as the ratio of the respective gene and the reference gene) in pediatric ALL and AML patients showed a large interindividual variability from 0.06 to 2.34, non-detectable to 0.06 and 0.04 to 0.30, respectively. 11896543 2002
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia 		0.030 GeneticVariation disease BEFREE We conclude that structural alteration of the coding region of the dCK gene represents one possible mechanism for ara-C resistance in vivo, but, considering the frequency of this event, other mechanisms may play a more important role for clinical resistance to ara-C in patients with AML. 7514246 1994