ACE, angiotensin I converting enzyme, 1636

N. diseases: 1082; N. variants: 82
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.900 Biomarker disease GENOMICS_ENGLAND
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.900 Biomarker disease GENOMICS_ENGLAND
CUI: C0266313
Disease: Allanson Pantzar McLeod syndrome
Allanson Pantzar McLeod syndrome 		0.760 Biomarker disease HPO
CUI: C0266313
Disease: Allanson Pantzar McLeod syndrome
Allanson Pantzar McLeod syndrome 		0.760 GeneticVariation disease CLINVAR
CUI: C0266313
Disease: Allanson Pantzar McLeod syndrome
Allanson Pantzar McLeod syndrome 		0.760 Biomarker disease GENOMICS_ENGLAND
CUI: C2675470
Disease: MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 3 (finding)
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 3 (finding) 		0.500 Biomarker disease GENOMICS_ENGLAND
CUI: C2675470
Disease: MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 3 (finding)
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 3 (finding) 		0.500 Biomarker disease CTD_human
CUI: C0020649
Disease: Hypotension
Hypotension 		0.400 Biomarker phenotype HPO
CUI: C0003460
Disease: Anuria
Anuria 		0.120 Biomarker phenotype HPO
CUI: C0025958
Disease: Microcephaly
Microcephaly 		0.100 Biomarker disease HPO
CUI: C0035229
Disease: Respiratory Insufficiency
Respiratory Insufficiency 		0.100 Biomarker phenotype HPO
CUI: C0079924
Disease: Oligohydramnios
Oligohydramnios 		0.100 Biomarker phenotype HPO
CUI: C0265783
Disease: Congenital hypoplasia of lung
Congenital hypoplasia of lung 		0.100 Biomarker disease HPO
CUI: C0266619
Disease: Potter's facies
Potter's facies 		0.100 Biomarker disease HPO
CUI: C1849300
Disease: Widely patent fontanelles and sutures
Widely patent fontanelles and sutures 		0.100 Biomarker phenotype HPO
CUI: C1862874
Disease: ANGIOTENSIN I-CONVERTING ENZYME, BENIGN SERUM INCREASE
ANGIOTENSIN I-CONVERTING ENZYME, BENIGN SERUM INCREASE 		0.100 CausalMutation phenotype CLINVAR
CUI: C4021821
Disease: Abnormality of the urinary system
Abnormality of the urinary system 		0.100 Biomarker disease HPO
CUI: C0036202
Disease: Sarcoidosis
Sarcoidosis 		0.100 Biomarker disease BEFREE An hypothetical model for the pathogenesis of sarcoidosis is presented which is compatible with its generalized nature, lack of an apparent etiologic agent and biochemical difference from other granulomas, including marked elevation of angiotensin converting enzyme. 940508 1976
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension 		0.100 GeneticVariation disease BEFREE The data thus provide evidence in favour of an association of HT with a polymorphism at the ACE locus (17q23), so implicating this locus, and possibly a genetic variant of ACE itself, in human essential hypertension. 1314601 1992
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.600 Biomarker disease CTD_human In a study comparing patients after myocardial infarction with controls, we have explored a possible association between coronary heart disease and a variation found in the gene encoding angiotensin-converting enzyme (ACE). 1328889 1992
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.600 AlteredExpression disease BEFREE Here we report that the DD genotype, which is associated with higher levels of circulating ACE than the ID and II genotypes, is significantly more frequent in patients with myocardial infarction (n = 610) than in controls (n = 733) (P = 0.007), especially among subjects with low body-mass index and low plasma levels of ApoB (P < 0.0001). 1328889 1992
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.400 GeneticVariation disease BEFREE The ACE/ID polymorphism seems to be a potent risk factor of coronary heart disease in subjects formerly considered to be at low risk according to common criteria. 1328889 1992
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.400 GeneticVariation disease BEFREE The ACE/ID polymorphism seems to be a potent risk factor of coronary heart disease in subjects formerly considered to be at low risk according to common criteria. 1328889 1992
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.400 GeneticVariation disease BEFREE The ACE/ID polymorphism seems to be a potent risk factor of coronary heart disease in subjects formerly considered to be at low risk according to common criteria. 1328889 1992
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 GeneticVariation group BEFREE We have found no evidence to support linkage between the ACE locus and hypertension, which suggests that mutations at the ACE locus do not commonly contribute to the pathogenesis of hypertension in our test population. 1338766 1992