|
Cerebrovascular Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
ABI = ankle-brachial index; ACEI = angiotensin-converting enzyme inhibitor; ARB = angiotensin II receptor blocker; BMI = body mass index; CAD = coronary artery disease; CI = confidence interval; CVA = cerebrovascular disease; DM = diabetes mellitus, DR = diabetic retinopathy; eGFR = estimated glomerular filtration rate; HbA1c = glycated hemoglobin A1c; HDL-C = high-density lipoprotein cholesterol; OR = odds ratio; PAOD = peripheral artery occlusive disease; TGs = triglycerides.
|
30048164 |
2018 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We screened 37 AD, 8 mild cognitive impairment (MCI), 3 AD and CVD (cerebrovascular disease), 3 MCI and CVD, 8 frontotemporal dementia (FTD) and 2 progressive supranuclear palsy (PSP) patients, and 28 normal controls (NCs).We sequenced PSEN1, PSEN2 and APP (EOAD risk factors), as well as MAPT, GRN and TARDBP for all cases and NCs, and analysed the APOE, CLU, CR1 and PICALM genotypes as well as the MAPT and ACE haplotypes (LOAD risk factors) for the AD (n = 37) and AD + MCI (n = 45) cases and NCs (n = 28).We identified variants in PSEN1, PSEN2 and TARDBP across a range of phenotypes (AD, AD and CVD, FTD and PSP), suggesting that screening of all known candidate genes of Alzheimer's and non-Alzheimer's forms of dementias in all dementia cases might be warranted.
|
26159191 |
2015 |
|
Cerebrovascular Disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
It has been reported that the deletion allele of the angiotensin-converting enzyme gene is associated with increased serum angiotensin-converting enzyme levels and linked to cerebrovascular diseases.
|
23278516 |
2013 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Four polymorphisms, located in the ACE (rs4291), angiotensinogen (rs5049) and (pro)renin receptor (rs2968915; rs5981008) genes were significantly associated with hypertension in two vascular disease populations of CAD (EUROPA) and cerebrovascular disease (PROGRESS; n = 3571).
|
21157371 |
2011 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Although angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphism is considered to have a role in hypertension, coronary artery disease, and myocardial infarction, its relationship with cerebrovascular disease and hypertension in stroke in different ethnic populations is still inconsistent.
|
19596363 |
2009 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We applied the measurement of IMT of carotid arteries by ultrasound imaging and the determination of the ACE insertion/deletion (I/D) polymorphism in blood to evaluate the predisposition for cerebrovascular disease in the offspring of patients with previous stroke.
|
15858957 |
2005 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The insertion/deletion (I/D) polymorphism of the angiotensin I converting enzyme (ACE) gene is believed to influence risk of cerebrovascular disease.
|
15465635 |
2004 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Controlling for racial background, there were no associations between ACE genotypes and cerebrovascular disease history or cardiovascular risk factors, including baseline blood pressure.
|
12925557 |
2003 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We postulate that the ACE gene polymorphism is a risk factor for cerebrovascular disease in dialytic patients.
|
12454231 |
2002 |
|
Cerebrovascular Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
We studied polymorphisms of mitochondrial DNA 5178cytosine/adenine (mt5178C/A) and angiotensin I-converting enzyme (ACE) genes (DCP1) in 127 cerebrovascular disorder (CVD) patients and 294 age-matched normal controls to clarify the genetic background of Japanese patients with CVD.
|
12039661 |
2002 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Apolipoprotein E epsilon4 and ACE genes have been related to several conditions involving cognitive impairment, including Alzheimer's disease, normal ageing and cerebrovascular disease.
|
12006218 |
2002 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The ACE insertion/deletion (I/D) polymorphism is an important candidate gene in ischaemic cerebrovascular disease but, where lacunar stroke specifically has been examined, there have been discrepant reports concerning a possible association.
|
11861692 |
2002 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The results showed that serum triglycerides concentration is elevated in stroke patients with the DD ACE genotype and it may be related to the risk of cerebrovascular disease associated with this polymorphism.
|
11720769 |
2001 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The relationship between cerebrovascular disease and an insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene is still being debated.
|
11859923 |
2001 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In conclusion, the ACE gene polymorphism affects plasma ACE activity but not blood pressure and is not associated with increased risk of myocardial infarction, ischemic heart disease, or ischemic cerebrovascular disease in the largest studies.
|
10669647 |
2000 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our results suggest that deletion polymorphism of the ACE gene is not associated with the pathogenesis of cerebrovascular disease in Taiwanese.
|
11155741 |
2000 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A polymorphism in the angiotensin I-converting enzyme (ACE) gene has been associated with cerebrovascular diseases as a new potent risk factor.
|
9785588 |
1998 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic risk factors and ischaemic cerebrovascular disease: role of common variation of the genes encoding apolipoproteins and angiotensin-converting enzyme.
|
9667803 |
1998 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The relationship between cerebrovascular disease and an insertion/deletion (I/D) polymorphism in intron 16 of the angiotensin-converting enzyme (ACE) gene is still being debated.
|
9242959 |
1997 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To investigate the association between ACE gene polymorphism and ischemic cerebrovascular disease.
|
9273825 |
1997 |
|
Cerebrovascular Disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The roles of the ACE insertion/deletion polymorphism and circulating ACE levels are unknown in cerebrovascular disease.
|
8610309 |
1996 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The ACE*D allele may be an independent risk factor for the development of cerebrovascular disease in hypertensive patients.
|
8653866 |
1996 |
|
Cerebrovascular Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
There was no significant association between angiotensin-converting enzyme genotype and cerebrovascular disease due to large-vessel stenosis.
|
7631331 |
1995 |