ACE, angiotensin I converting enzyme, 1636

N. diseases: 1082; N. variants: 82
Disease: Male infertility ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021364
Disease: Male infertility
Male infertility 		0.330 AlteredExpression phenotype BEFREE In conclusion, up to the present time, captopril does not appear to induce a striking change in semen quality, and hence on male infertility, while it may affect the rate of spermatozoa-egg fusion as it inhibits the activity of angiotensin-converting enzyme that is released during capacitation and the acrosome reaction. 27444248 2017
CUI: C0021364
Disease: Male infertility
Male infertility 		0.330 GeneticVariation phenotype BEFREE Thus, these ACE gene polymorphisms are unlikely to contribute to the pathogenesis of male infertility in the Singapore Chinese population. 11870238 2002
CUI: C0021364
Disease: Male infertility
Male infertility 		0.330 Biomarker phenotype BEFREE The ACE gene knockout mice lack both isozymes and they exhibit low blood pressure, kidney dysfunctions, and male infertility. 9664078 1998
CUI: C0021364
Disease: Male infertility
Male infertility 		0.330 Biomarker phenotype CTD_human Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. 8642790 1996