|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Specific to CKD, targeting a low blood pressure and reduction in albuminuria with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers may slow cognitive decline, albeit modestly.
|
31378643 |
2019 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Observational Study of Brain Atrophy and Cognitive Decline Comparing a Sample of Community-Dwelling People Taking Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Over Time.
|
30909218 |
2019 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cognitive impairment at 3 years affected all ACE-R subdomains and was associated with ACE-R 1 year (β=1.054, p<0.001) and NART (β=1.023, p<0.05).
|
30554134 |
2019 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, ACE inhibition represents a strong candidate for clinical trials aimed at mitigating cognitive dysfunction.
|
30185634 |
2018 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Scores of cognitive mobile games could be used as an alternative to MMSE and ACE-R to evaluate cognitive function of aged people with and without cognitive impairment at least when MMSE is higher than 20/30.
|
29991133 |
2018 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
The large RJE tertile performed significantly poorer in measures of global cognition (ACE-R; OR 0.54 95%CI 0.31-0.95) and executive function (Trail Making Test B; OR 1.84 95%CI 1.00-3.36) and had increased concern about falling (Falls Efficacy Scale-International; OR 2.01 95% CI 1.06-3.79) compared to the minimal RJE tertile.
|
30389580 |
2018 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results indicated that the ACE-R and MoCA had good discriminative ability in detection of cognitive impairment, with areas under the receiver-operating characteristic (ROC) curve of .85 (95% confidence interval, CI [.75.
|
28436744 |
2018 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accumulating evidence suggests that the use of angiotensin-converting enzyme inhibitor (ACE-I) medication protects against cognitive decline in the elderly patients.
|
28449585 |
2017 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Nearly two-thirds of participants screened positive for cognitive impairment on the ACE-R; 41% and 65% of clients met the cut-off scores for mild cognitive impairment (MCI) and more severe cognitive impairment, respectively.
|
28143626 |
2017 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Addenbrooke's Cognitive Examination III (ACE-III), an adaptation of the ACE cognitive screening test, has been demonstrated to have high sensitivity and specificity in detecting cognitive impairment in patients with dementia and other neurological and psychiatric disorders.
|
28865943 |
2017 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The ACE D allele in aMCI patients may increase the risk of cognitive impairment.
|
28870562 |
2017 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An additional aim was to examine the accuracy of the ACE-R to detect dementia and cognitive impairment no dementia (CIND).
|
28511735 |
2017 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, patients with aMCI could take ACE inhibitor (ACEI) to decrease the incidence of AD, and patients with AD could take ACEI to retard cognitive decline in early AD.
|
27608957 |
2016 |
|
Impaired cognition
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these studies show that increased myelomonocytic ACE expression in mice alters the immune response to better defend against many different types of pathologic insult, including the cognitive decline observed in an animal model of AD.
|
24792094 |
2014 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
At the level of genotypic association, we confirmed that the APOE ε4 homozygote significantly accelerated cognitive decline and found that carriers of the ACE rs1800764_C allele were more likely to show cognitive decline than noncarriers, particularly in those without college education.
|
24863667 |
2014 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the ACE I/D polymorphism can modulate the pathology of RGD, and the status of geriatric depression and the ACE-D allele may synergistically induce altered resting state network activity, which could influence the cognitive function and increase the mortality risk for cognitive impairment.
|
22348891 |
2012 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The ACE-DD genotype may be associated with post-stroke cognitive decline while the APOE-epsilon4 allele is not.
|
20606435 |
2010 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this sample of young and middle-aged adults with Type 1 diabetes, APO epsilon4 and ACE D alleles do not appear to increase risk of cognitive dysfunction.
|
20121884 |
2010 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
The finding suggests that ACE can modulates the pathology of RGD, the left MTG and right ACG might be involved in the pathophysiology of cognitive dysfunction in RGD patients.
|
20639003 |
2010 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a UK community sample of 148 African-Caribbean people aged 55-75 years, we investigated the association between ACE genotype and cognitive decline over 3 years using a battery of repeated tests.
|
15465635 |
2004 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The ACE genotype was not associated with the long-term risks of stroke, cardiac events, mortality, dementia, or cognitive decline; neither did the ACE genotype predict the blood pressure reduction associated with the use of the ACE inhibitor perindopril.
|
12925557 |
2003 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E epsilon4 and ACE genes have been related to several conditions involving cognitive impairment, including Alzheimer's disease, normal ageing and cerebrovascular disease.
|
12006218 |
2002 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover, the combined effect of the presence of at least one APOE epsilon4 allele and ACE DD homozygosity was a risk factor for cognitive decline.
|
10794851 |
2000 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E and ACE genes have both been associated with cognitive impairment in aging and dementia.
|
10549798 |
1999 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The ACE DD genotype carriers had an increased risk of cognitive impairment (OR = 1.60, 95% CI (1.04-2.36), P < 0.03), independent of other risk factors of cognitive impairment: age, gender and presence of the apolipoprotein E epsilon 4 allele.
|
8916108 |
1996 |