ACE, angiotensin I converting enzyme, 1636

N. diseases: 1082; N. variants: 82
Disease: Pregnancy associated hypertension ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0852036
Disease: Pregnancy associated hypertension
Pregnancy associated hypertension 		0.290 GeneticVariation phenotype BEFREE Correlation of ACE gene deletion/insertion polymorphism and risk of pregnancy-induced hypertension: a meta-analysis based on 10,236 subjects. 26071453 2015
CUI: C0852036
Disease: Pregnancy associated hypertension
Pregnancy associated hypertension 		0.290 Biomarker phenotype BEFREE Stratified analyses were conducted as meta-regression analysis indicated that the sample size of case group was a significant source of heterogeneity, which suggested no significant association between ACE I/D and PIH in the subgroup of more than 100 cases. 22644634 2012
CUI: C0852036
Disease: Pregnancy associated hypertension
Pregnancy associated hypertension 		0.290 GeneticVariation phenotype BEFREE Nor is there any evidence that the incompatibility of fetal and maternal ACE genotype is associated with PIH in the studied population. 21250908 2011
CUI: C0852036
Disease: Pregnancy associated hypertension
Pregnancy associated hypertension 		0.290 GeneticVariation phenotype BEFREE Frequencies of NOS3 G894T, 4b/a and T(-786) --> C, AGT T704C and ACE ins/del polymorphisms were studied in 342 subjects: 120 with preeclampsia (PE), 104 with gestational hypertension and 118 normotensive pregnant women. 20186148 2010
CUI: C0852036
Disease: Pregnancy associated hypertension
Pregnancy associated hypertension 		0.290 GeneticVariation phenotype BEFREE Angiotensin-converting enzyme and adducin-1 polymorphisms in women with preeclampsia and gestational hypertension. 19443911 2009
CUI: C0852036
Disease: Pregnancy associated hypertension
Pregnancy associated hypertension 		0.290 Biomarker phenotype RGD ACE2 and ANG-(1-7) in the rat uterus during early and late gestation. 17977916 2008
CUI: C0852036
Disease: Pregnancy associated hypertension
Pregnancy associated hypertension 		0.290 GeneticVariation phenotype BEFREE T235 of AGT, C1166 of AT1 and Asp298 of NOS3 were respectively associated with HP, although no significant associations were found between the common genetic variants and HP in ACE, FV, MTHFR, B3AR, TNF-A, PAI-1, GSTP1, mEH, and LPL. 16369102 2006
CUI: C0852036
Disease: Pregnancy associated hypertension
Pregnancy associated hypertension 		0.290 GeneticVariation phenotype BEFREE However, the ACE genotype was similar in different categories of PIH and did not affect the perinatal outcome. 16167906 2005
CUI: C0852036
Disease: Pregnancy associated hypertension
Pregnancy associated hypertension 		0.290 GeneticVariation phenotype LHGDN The angiotensin-converting enzyme (ACE) insertion/deletion, angiotensinogen M235T and angiotensin II receptor type 1 1166A<--C polymorphisms were assessed in study groups comprising 204 women with pre-eclampsia, 120 with eclampsia, 67 with early onset pre-eclampsia and 78 with gestational hypertension. 15097234 2004
CUI: C0852036
Disease: Pregnancy associated hypertension
Pregnancy associated hypertension 		0.290 GeneticVariation phenotype BEFREE Patients with gestational hypertension were less frequently homozygous for the ACE insertion polymorphism compared with controls (5 versus 13%, respectively; P = 0.049; odds ratio 0.36 [95% confidence interval (CI) 0.09-1.04]). 15097234 2004
CUI: C0852036
Disease: Pregnancy associated hypertension
Pregnancy associated hypertension 		0.290 GeneticVariation phenotype BEFREE There was no effect of ACE gene polymorphism on pregnancy outcome, the incidence of pregnancy-induced hypertension, or changes in BP during pregnancy. 8841206 1996