|
Acute myocardial infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This strategy of inhibiting IL28RA gene expression may reduce reperfusion injury in the treatment of patients with acute myocardial infarction.
|
28639948 |
2017 |
|
Allergic rhinitis (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results suggested that the g.32349 G>A polymorphism of IL-28RA might be associated with susceptibility to allergic rhinitis (P=0.032), but seems to have no relationship with serum total IgE levels.
|
16819289 |
2006 |
|
Arthritis, Psoriatic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study provides evidence for the involvement of ERAP1, IL28RA, GJB2 and PTTG1 loci in PsA susceptibility and confirmed the previously reported association with PsA and PsV.
|
23252691 |
2013 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
We did not find any consistent association between IL28RA and MS in these populations, suggesting that, although it may play a role in other autoimmune diseases, this gene is unlikely of general relevance to MS pathogenesis.
|
22386267 |
2012 |
|
Bronchiolitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Airway IFNLR1 transcript levels were significantly higher in HRV bronchiolitis infants compared to those with RSV bronchiolitis.
|
29549834 |
2018 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found human IL28RA was expressed in lymphs, testes, lymphoma, teratocarcinoma, pediatric pre-B cell acute lymphoblastic leukemia, germinal center B cells, embryonic stem cells, fetal lung, and also expressed in bladder, blood and breast cancers, glioma, head and neck cancer and lung cancer tissues.
|
20372826 |
2010 |
|
Degenerative polyarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry revealed that both IL-29 and IL-28Ra were dramatically elevated in OA synovium compared to HC; synovial fibroblasts (FLS) and macrophages were the main IL-29-producing cells in OA synovium.
|
27433031 |
2016 |
|
Eosinophilia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that IFNLR1 are increased in HRV-infected infants with more severe bronchiolitis and blood eosinophilia and in those infected with the HRVC species.
|
29549834 |
2018 |
|
Eosinophilic disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
These results suggest that IFNLR1 are increased in HRV-infected infants with more severe bronchiolitis and blood eosinophilia and in those infected with the HRVC species.
|
29549834 |
2018 |
|
Hepatitis B
|
0.020 |
Biomarker
|
disease |
BEFREE |
This study was conducted to determine whether polymorphisms near or in interferon-lambda (IFN-λs) genes and their receptor genes such as interleukin 28 receptor, alpha (IL28RA) and interleukin 10 receptor, beta (IL10RB) as well as p21-activated kinases 4 (PAK4) and iron/zinc purple acid phosphatase-like protein (PAPL), which are locate upstream of IFN-λs, and lastly the DEPDC5 gene are associated with hepatitis B virus-related liver disease in Han Chinese.
|
25032264 |
2014 |
|
Hepatitis B
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Significant associations were observed for 4 variants in IFNAR2, IFNLR1 with HBV infection, and IFNLR1-rs4649203 was associated with HBV recovery.
|
29080269 |
2018 |
|
Hepatitis C
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Zinc interferes with IFN-λ3 binding to IFNL receptor 1 (IFNLR1), resulting in decreased antiviral activity and increased viral replication (HCV, influenza) in vitro.
|
28513591 |
2017 |
|
Hepatitis C
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Haplotype analysis showed that IL28RA rs10903035-rs11249006 haplotype GG played a protective effect for HCV infection (OR=0.21, 95%CI=0.13-0.36, P<0.001; OR=0.20, 95%CI=0.12-0.34, P<0.001).
|
21742059 |
2011 |
|
Hepatitis C
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Here, we determined the expression of IFNL3 and its receptor IFNLR1 in blood immune cell subsets and in HCV-infected livers.
|
24045339 |
2014 |
|
Hepatitis C
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
IL28RA polymorphism is associated with early hepatitis C virus (HCV) treatment failure in human immunodeficiency virus-/HCV-coinfected patients.
|
23565619 |
2013 |
|
Hepatitis C
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The distribution of IL10RB and IL28RA genotypes among the HCV-infected and control groups did not differ significantly.
|
24144988 |
2014 |
|
Hepatitis C
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate the association of interleukin 28B (IL28B) and interleukin 28 receptor alpha (IL28RA) polymorphisms with IR among human immunodeficiency virus (HIV)/HCV-coinfected patients.
|
24438680 |
2014 |
|
Hepatitis C, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies.
|
24752298 |
2014 |
|
Herpes encephalitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The first set represented eleven non-synonymous variants in six different genes involved in interferon (IFN) induction, present in a cohort of patients suffering from herpes simplex encephalitis (HSE) and the second set represented sixteen allelic variants of the IFNLR1 gene.
|
29217828 |
2019 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
IL28RA polymorphism is associated with early hepatitis C virus (HCV) treatment failure in human immunodeficiency virus-/HCV-coinfected patients.
|
23565619 |
2013 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate the association of interleukin 28B (IL28B) and interleukin 28 receptor alpha (IL28RA) polymorphisms with IR among human immunodeficiency virus (HIV)/HCV-coinfected patients.
|
24438680 |
2014 |
|
Infection by Trichuris trichiura
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings demonstrate that whilst IL-22Rα and IL-28Rα are dispensable in the host response to whipworms, IL-10 signalling through IL-10Rα and IL-10Rβ is essential to control caecal pathology, worm expulsion and survival during T. muris infections.
|
30640950 |
2019 |
|
Inflammatory Bowel Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Colonic biopsies and resected tissue from patients with IBD (n = 62) and patients without colon inflammation (controls, n = 23) were analyzed by quantitative polymerase chain rection to measure expression of IL28A, IL28RA, and other related cytokines; biopsy samples were also analyzed by immunofluorescence to identify sources of IL28 production.
|
28342759 |
2017 |
|
Liver diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
This study was conducted to determine whether polymorphisms near or in interferon-lambda (IFN-λs) genes and their receptor genes such as interleukin 28 receptor, alpha (IL28RA) and interleukin 10 receptor, beta (IL10RB) as well as p21-activated kinases 4 (PAK4) and iron/zinc purple acid phosphatase-like protein (PAPL), which are locate upstream of IFN-λs, and lastly the DEPDC5 gene are associated with hepatitis B virus-related liver disease in Han Chinese.
|
25032264 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results showed that two common susceptibility loci (NFKBIA and IL28RA) are shared by psoriasis and SLE in the Chinese Han population.
|
24070858 |
2013 |