|
Progressive sensorineural hearing impairment
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
<b>Results</b> We identified a cosegregating heterozygous missense mutation, c.296G>A (p.Arg99His) in the gene encoding interferon lambda receptor 1 (<i>IFNLR1</i>) - a protein that functions in the Jak/ STAT pathway- are associated with <i>ADNSHL</i> Morpholino knockdown of ifnlr1 leads to a significant decrease in hair cells and non-inflation of the swim bladder in late-stage zebrafish, which can be reversed by injection with normal Zebrafish <i>ifnlr1</i> mRNA.
|
29453195 |
2018 |
|
Hepatitis C
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
IL28RA polymorphism is associated with early hepatitis C virus (HCV) treatment failure in human immunodeficiency virus-/HCV-coinfected patients.
|
23565619 |
2013 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
IL28RA polymorphism is associated with early hepatitis C virus (HCV) treatment failure in human immunodeficiency virus-/HCV-coinfected patients.
|
23565619 |
2013 |
|
Hepatitis C, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies.
|
24752298 |
2014 |
|
Rhinovirus infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interferon lambda receptor 1 (IFNL1R) transcript is highly expressed in rhinovirus bronchiolitis and correlates with disease severity.
|
29549834 |
2018 |
|
Pancreatic carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IL28RA is lowly expressed in pancreatic cancer patients, and has certain diagnostic value for early pancreatic cancer.
|
31799654 |
2019 |
|
Malignant neoplasm of pancreas
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IL28RA is lowly expressed in pancreatic cancer patients, and has certain diagnostic value for early pancreatic cancer.
|
31799654 |
2019 |
|
Psoriasis
|
0.330 |
Biomarker
|
disease |
CTD_human |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |
|
Pustulosis of Palms and Soles
|
0.300 |
Biomarker
|
disease |
CTD_human |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |
|
Bronchiolitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Airway IFNLR1 transcript levels were significantly higher in HRV bronchiolitis infants compared to those with RSV bronchiolitis.
|
29549834 |
2018 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Airway IFNLR1 transcript levels were significantly higher in HRV bronchiolitis infants compared to those with RSV bronchiolitis.
|
29549834 |
2018 |
|
Multiple Sclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis.
|
22386267 |
2012 |
|
Rhinitis
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
Analysis of the variations in IL-28RA gene and their association with allergic rhinitis.
|
16819289 |
2006 |
|
Inflammatory Bowel Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Colonic biopsies and resected tissue from patients with IBD (n = 62) and patients without colon inflammation (controls, n = 23) were analyzed by quantitative polymerase chain rection to measure expression of IL28A, IL28RA, and other related cytokines; biopsy samples were also analyzed by immunofluorescence to identify sources of IL28 production.
|
28342759 |
2017 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
From nasopharyngeal washings' cells (46 positive to NA1, 47 to ON1 and 28 to RSV-B, genotype BA), the mRNA copy number of the type III IFN receptor (IFNLR1 and IL10RB subunits), and of the type I/III IFN-stimulated genes, MxA and ISG56, was calculated using the threshold cycle relative quantification method with respect to an invariant gene.
|
31485724 |
2020 |
|
Hepatitis C
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Haplotype analysis showed that IL28RA rs10903035-rs11249006 haplotype GG played a protective effect for HCV infection (OR=0.21, 95%CI=0.13-0.36, P<0.001; OR=0.20, 95%CI=0.12-0.34, P<0.001).
|
21742059 |
2011 |
|
Hepatitis C
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Here, we determined the expression of IFNL3 and its receptor IFNLR1 in blood immune cell subsets and in HCV-infected livers.
|
24045339 |
2014 |
|
Degenerative polyarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry revealed that both IL-29 and IL-28Ra were dramatically elevated in OA synovium compared to HC; synovial fibroblasts (FLS) and macrophages were the main IL-29-producing cells in OA synovium.
|
27433031 |
2016 |
|
Lymphocytic Choriomeningitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In agreement with this observation, we showed that LCMV infection significantly reduces IFNLR1 mRNA expression in infected cells.
|
25830339 |
2015 |
|
Non-arthropod borne lymphocytic choriomeningitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In agreement with this observation, we showed that LCMV infection significantly reduces IFNLR1 mRNA expression in infected cells.
|
25830339 |
2015 |
|
Sjogren's Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we sought to investigate the expression of type III IFNs and their common receptor IFN-λR1/IL-28Ra in Sjögren's syndrome (SS).
|
27613139 |
2016 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Meta-analysis of the prognostic value of IL28RA genes in various cancers found that the expression of IL28RA was indeed related to the cancer prognosis in certain cancers.
|
20372826 |
2010 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Meta-analysis of the prognostic value of IL28RA genes in various cancers found that the expression of IL28RA was indeed related to the cancer prognosis in certain cancers.
|
20372826 |
2010 |
|
Infection by Trichuris trichiura
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings demonstrate that whilst IL-22Rα and IL-28Rα are dispensable in the host response to whipworms, IL-10 signalling through IL-10Rα and IL-10Rβ is essential to control caecal pathology, worm expulsion and survival during T. muris infections.
|
30640950 |
2019 |
|
Allergic rhinitis (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results suggested that the g.32349 G>A polymorphism of IL-28RA might be associated with susceptibility to allergic rhinitis (P=0.032), but seems to have no relationship with serum total IgE levels.
|
16819289 |
2006 |