DCX, doublecortin, 1641

N. diseases: 175; N. variants: 107
Disease: Caffeine related disorders ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0236734
Disease: Caffeine related disorders
Caffeine related disorders 		0.020 AlteredExpression group BEFREE In contrast, caffeine alone reduced proliferative capacity and expression of the neuronal markers DCX and NeuN at 6 h, but increased expression of neurotrophins and neuronal transcription factors at 6 and 12 h. These results indicate that administration of phenobarbital during the vulnerable phase of brain development negatively interferes with neuronal development, which can be prevented in part by co-administration of caffeine. 29417440 2018
CUI: C0236734
Disease: Caffeine related disorders
Caffeine related disorders 		0.020 Biomarker group BEFREE Reduced doublecortin immunoreactivity in the dentate gyrus relative to controls was seen in the CafSuc, but not Suc, treatment conditions. 29729502 2018