DCX, doublecortin, 1641

N. diseases: 175; N. variants: 107
Disease: Impaired cognition ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.030 GeneticVariation disease BEFREE Whilst many of these pathogenic DCX mutations are within the doublecortin domains (DC1 and DC2) that mediate direct DCX-MT association, a pathogenic mutation DCX E2K that causes cognitive impairment and pachygyria in human patients lies within the regulatory DCX N-terminus (DCX-N) preceding the DC1 domain. 30979500 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.030 AlteredExpression disease BEFREE GM-CSF treatment in AD mice reduced brain amyloidosis, increased plasma Aβ, and rescued cognitive impairment with increased hippocampal expression of calbindin and synaptophysin and increased levels of doublecortin-positive cells in the dentate gyrus. 29573847 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.030 AlteredExpression disease BEFREE HBO-PC increased pNF-H and DCX expression and mitigated cognitive deficits in MCAO rats. 28937253 2017