CFD, complement factor D, 1675

N. diseases: 83; N. variants: 4
Disease: Intracranial Aneurysm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007766
Disease: Intracranial Aneurysm
Intracranial Aneurysm 		0.020 Biomarker disease BEFREE We use the models to study intracranial aneurysm flow in 54 subjects under rest and exercise and conclude that OSI, a common wall shear-stress derived quantity in vascular CFD studies, may be too sensitive to flow fluctuations to be a reliable biomarker. 31691518 2020
CUI: C0007766
Disease: Intracranial Aneurysm
Intracranial Aneurysm 		0.020 Biomarker disease BEFREE Finally, CFD and immunofluorescence on human intracranial aneurysms showed a correlation similar to the mouse vessels, suggesting that disturbed shear stress may lead to sustained NF-kB activation thereby offering an explanation for the close association between disturbed flow and intracranial aneurysms. 30894565 2019