|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Taken together, these results reveal downregulation of Notch signaling and Mist1 expression during the initiation of Kras-driven gastric tumorigenesis and suggest a tumor-suppressive role for Notch in this context.
|
31276933 |
2019 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
In vivo, overexpression of MIST1 retarded tumor xenograft growth and decreased tumor cell dissemination to the liver.
|
29859299 |
2018 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
In this study, we tested whether induced MIST1 or PTF1a expression in PDAC cells could (i) re-establish the transcriptional program of differentiated acinar cells and (ii) simultaneously reduce tumor cell properties.
|
29719936 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Kras activation in Mist1(+) adult acinar cells resulted in brisk PanIN formation, whereas no evidence of pancreatic neoplasia was observed for up to 6 months following Kras activation in Hnf1beta(+) adult ductal cells.
|
26592447 |
2016 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Thus, while BC-mixture up-regulated the expression of oncogenes associated to breast cancer (GFRA1 and BHLHB8), the H-mixture down-regulated the expression of tumor suppressor genes (EPHA4 and EPHB2).
|
26853153 |
2016 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study, we tested whether induced MIST1 or PTF1a expression in PDAC cells could (i) re-establish the transcriptional program of differentiated acinar cells and (ii) simultaneously reduce tumor cell properties.
|
29719936 |
2018 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results suggest that the loss of MIST1 is a common event during PDAC and CP and events that affect MIST1 function and expression may increase susceptibility to these pathologies.
|
22374815 |
2012 |
|
Acinar Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
When moderate-to-strong Mist1 staining was used as the criterion of positivity, all the tested salivary gland tumours other than AciCC were negative for Mist1, except for two cases of SC.
|
31187185 |
2019 |
|
Acinic cell carcinoma of salivary gland
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mist1: a novel nuclear marker for acinic cell carcinoma of the salivary gland.
|
31187185 |
2019 |
|
Secretory breast carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry (IHC) was used to analyse Mist1 expression in AciCC (n = 26), secretory carcinoma (SC; n = 18) and 12 other types of salivary gland tumours (n = 99).
|
31187185 |
2019 |
|
Carcinogenesis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Taken together, these results reveal downregulation of Notch signaling and Mist1 expression during the initiation of Kras-driven gastric tumorigenesis and suggest a tumor-suppressive role for Notch in this context.
|
31276933 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of MIST1 in lymph node metastases correlated significantly with the number of lymph node metastases as well as overall and tumor-specific survival.
|
31827644 |
2019 |
|
Pancreatic carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In vitro, overexpression of MIST1 reduced pancreatic cancer cell growth, migration, and invasion.
|
29859299 |
2018 |
|
Malignant neoplasm of pancreas
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In vitro, overexpression of MIST1 reduced pancreatic cancer cell growth, migration, and invasion.
|
29859299 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In vitro, overexpression of MIST1 reduced pancreatic cancer cell growth, migration, and invasion.
|
29859299 |
2018 |
|
Dry Eye Syndromes
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, we found extensive loss of MIST1+ secretory acinar cells in the Aire -/- lacrimal gland suggesting that acinar cells are a primary target of the disease, Finally, topical application of ophthalmic steroid effectively restored corneal innervation in Aire -/- mice thereby functionally linking nerve loss with local inflammation in the aqueous-deficient dry eye.
|
28926640 |
2017 |
|
Dryness of eye
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In addition, we found extensive loss of MIST1+ secretory acinar cells in the Aire -/- lacrimal gland suggesting that acinar cells are a primary target of the disease, Finally, topical application of ophthalmic steroid effectively restored corneal innervation in Aire -/- mice thereby functionally linking nerve loss with local inflammation in the aqueous-deficient dry eye.
|
28926640 |
2017 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Thus, while BC-mixture up-regulated the expression of oncogenes associated to breast cancer (GFRA1 and BHLHB8), the H-mixture down-regulated the expression of tumor suppressor genes (EPHA4 and EPHB2).
|
26853153 |
2016 |
|
Pancreatic Neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Owing to the high incidence of p53 mutations in PanIN 3 lesions and pancreatic tumors, we interrogated the comparative ability of adult pancreatic acinar and ductal cells to respond to oncogenic Kras and mutant Tp53(R172H) using Hnf1b:CreER(T2) and Mist1:CreER(T2) mice.
|
26592447 |
2016 |
|
Intestinal metaplasia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Mist1-Kras mice developed metaplastic glands, which completely replaced normal fundic lineages and progressed to IM within 3-4 months after tamoxifen injection.
|
26677984 |
2016 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Thus, while BC-mixture up-regulated the expression of oncogenes associated to breast cancer (GFRA1 and BHLHB8), the H-mixture down-regulated the expression of tumor suppressor genes (EPHA4 and EPHB2).
|
26853153 |
2016 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Mist1(+) stem cells serve as a cell-of-origin for intestinal-type cancer with the combination of Kras and Apc mutation and for diffuse-type cancer with the loss of E-cadherin.
|
26585400 |
2015 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Mist1(+) stem cells serve as a cell-of-origin for intestinal-type cancer with the combination of Kras and Apc mutation and for diffuse-type cancer with the loss of E-cadherin.
|
26585400 |
2015 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased Hspa5 and Chop expression were found in dysplasia of C57Bl/6 mice with chronic H. felis infection but was absent in spontaneous gastric dysplasia in K19-Wnt1/C2mE mice with concomitant loss of Mist1 expression, similar to that observed in H. pylori-associated human GC.
|
23108377 |
2013 |
|
Polyendocrinopathies, Autoimmune
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Ten of the 12 PGAs also unexpectedly exhibited focal expression of pepsinogen-I and MIST1, suggesting that PGAs often show focal chief cell differentiation and phenotypically resemble mucous neck cells rather than pyloric glands.
|
23782334 |
2013 |