|
Multiple Myeloma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.
|
23955597 |
2013 |
|
Multiple Myeloma
|
0.400 |
GeneticVariation
|
disease |
GWASDB |
Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.
|
23955597 |
2013 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression.
|
30626913 |
2019 |
|
Oral Ulcer
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci.
|
30837455 |
2019 |
|
Uric acid measurement (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.
|
30993211 |
2019 |
|
Major Depressive Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression.
|
30626913 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.
|
28552196 |
2017 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Defining the role of common variation in the genomic and biological architecture of adult human height.
|
25282103 |
2014 |
|
Systemic Scleroderma
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.
|
21750679 |
2011 |
|
Systemic Scleroderma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.
|
21750679 |
2011 |
|
Psoriasis
|
0.030 |
GeneticVariation
|
disease |
LHGDN |
Correlation of HLA-Cw*06 allele frequency with some clinical features of psoriasis vulgaris in the population of northern Poland.
|
15523160 |
2004 |
|
Psoriasis
|
0.030 |
Biomarker
|
disease |
BEFREE |
SPR1 gene near HLA-C is unlikely to be a psoriasis susceptibility gene.
|
12823445 |
2003 |
|
Psoriasis
|
0.030 |
GeneticVariation
|
disease |
LHGDN |
In a case-control study, five of the nine single nucleotide polymorphisms (SNPs) found in SEEK1 were associated with psoriasis, while one of the four SNPs found in SPR1 showed association.
|
12930300 |
2003 |
|
Psoriasis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Both SEEK1 and SPR1 are expressed in normal and psoriasis skin.
|
12930300 |
2003 |
|
Malignant transformation
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
In these latter cell lines representing advanced malignant transformation, there was a loss of up- and downregulation, respectively, by the phorbol ester and vitamin A. Transfection study with chimeric constructs of the SPR1 promoter and a reporter gene showed that the dysregulation of SPR1 expression in malignant transformation was a result of perturbation of the basal and enhancer elements of the first 162 nucleotides in the 5'-flanking promoter region of the SPR1 gene.
|
10615070 |
2000 |
|
Malignant transformation
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Because the spr1 protein is a component of the crosslinked envelope that forms during the squamous differentiation process, we hypothesize that the apparent loss of spr1 gene expression disrupts mechanisms for terminal squamous differentiation in the bronchial epithelium, thereby contributing to malignant transformation.
|
9651177 |
1998 |
|
Psoriasis vulgaris
|
0.010 |
Biomarker
|
disease |
BEFREE |
No significantly different allelic distribution of 13 SPR1 SNPs could be found between the patients with PV and controls after correction for multiple testing.
|
12823445 |
2003 |
|
Carcinogenesis
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
These findings suggest an association of transcriptional dysregulation of the SPR1 gene with multistep bronchial carcinogenesis.
|
10615070 |
2000 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Re-expression of SPR1 in breast cancer cells by phorbol 12-myristate 13-acetate (PMA) or UV irradiation is mediated by the AP-1 binding site in the SPR1 promoter.
|
10501656 |
1999 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
SPR1 presents an example of class II genes, since its expression was up-regulated in tumor cells by phorbol 12-myristate 13-acetate (PMA) or by ultraviolet (UV) irradiation.
|
10501656 |
1999 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Re-expression of SPR1 in breast cancer cells by phorbol 12-myristate 13-acetate (PMA) or UV irradiation is mediated by the AP-1 binding site in the SPR1 promoter.
|
10501656 |
1999 |
|
Mammary Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The SPR1 gene was identified by differential display on the basis of its reduced or absent expression in human breast tumor cell lines compared to normal mammary epithelial cell strains.
|
10501656 |
1999 |
|
Bronchogenic Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Loss of spr1 expression measurable by quantitative RT-PCR in human bronchogenic carcinoma cell lines.
|
9651177 |
1998 |