|
Aortic Valve Stenosis
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Indications for TAVR were severe degenerative aortic stenosis (AS; 94.7%) or re-stenosis after surgical AVR (5.3%).
|
30972479 |
2019 |
|
Aortic Valve Stenosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
These findings suggest that TAVR may be the preferred option over SAVR in low-risk patients with severe AS who are candidates for bioprosthetic AVR.
|
31537261 |
2019 |
|
Aortic Valve Stenosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
Conclusions Consistent with animal studies, arterial wave reflections are associated with interstitial volume expansion in severe aortic stenosis and predict a smaller improvement in quality of life following AVR .
|
30590991 |
2019 |
|
Aortic Valve Stenosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
Compared to HG-AS, LG-AS is less likely to benefit from an AVR and had a significantly worse outcome.
|
31705575 |
2019 |
|
Aortic Valve Stenosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
Several non-randomized studies and meta-analyses have suggested benefit from early AVR for asymptomatic severe AS, including improved all-cause, cardiovascular, and valve-related mortality.
|
30311005 |
2018 |
|
Aortic Valve Stenosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
Consecutive patients who underwent AVR in University Hospital Center Zagreb for isolated severe symptomatic AS and preserved EF were enrolled.
|
27866867 |
2017 |
|
Aortic Valve Stenosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
The initial AVR strategy was associated with better outcomes than the conservative strategy in both HG-AS and LG-AS patients, although AVR was less frequently performed in LG-AS patients than in HG-AS patients.
|
28500139 |
2017 |
|
Aortic Valve Stenosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
Low-flow AS states have poor prognoses, thus AVR and especially TAVR have a growing role in treatment of this challenging subset of AS patients.
|
29086035 |
2017 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
In this study, we aim to explore the role of NLRP3 and NLRP6 inflammasome in lung tumorigenesis in the animal model that we set up previously.
|
31561077 |
2019 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Our results unveil an unexpected, pathogenic role for host NLRP6 in gastrointestinal GVHD that is independent of variations in the intestinal microbiome and in contrast to its well-appreciated microbiome-dependent protective role in intestinal colitis and tumorigenesis.
|
30858572 |
2019 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Correction: NLRP6 targeting suppresses gastric tumorigenesis via P14<sup>ARF</sup>-Mdm2-P53-dependent cellular senescence.
|
30464807 |
2018 |
|
Carcinogenesis
|
0.050 |
GeneticVariation
|
phenotype |
BEFREE |
Nod-like receptor pyrin domain-containing protein 6 (NLRP6), a component of inflammasome, has been linked to colorectal tumorigenesis.
|
30568504 |
2018 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Previous studies reported a protective role for NLRP6 against intestinal injury and colitis-associated carcinogenesis via the regulation and establishment of a healthy microbiota.
|
29281815 |
2017 |
|
Colitis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our results unveil an unexpected, pathogenic role for host NLRP6 in gastrointestinal GVHD that is independent of variations in the intestinal microbiome and in contrast to its well-appreciated microbiome-dependent protective role in intestinal colitis and tumorigenesis.
|
30858572 |
2019 |
|
Colitis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Collectively, these data indicate that apigenin modulated an inflammasome-independent mechanism by which Nlrp6 reprograms the gut microbiota for protecting mice against colitis.
|
29139477 |
2018 |
|
Colitis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate that A. muciniphila can act as a pathobiont to promote colitis in a genetically susceptible host and that NLRP6 is a key regulator of its abundance.
|
28445725 |
2017 |
|
Colitis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our results clarify the role of NLRP6 in microbiota and colitis control, and they highlight the importance of analyzing littermate animals in such studies.
|
29281815 |
2017 |
|
Malignant neoplasm of stomach
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In terms of mechanism, OIP5-AS1 directly bound to EZH2 and obstructed NLRP6 expression, speeding up GC progression.
|
31219209 |
2020 |
|
Stomach Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In terms of mechanism, OIP5-AS1 directly bound to EZH2 and obstructed NLRP6 expression, speeding up GC progression.
|
31219209 |
2020 |
|
Aortic Valve Insufficiency
|
0.030 |
Biomarker
|
disease |
BEFREE |
At 5 years, freedom from >2+ AI was 97% and freedom from AVR was 96%.
|
30292845 |
2019 |
|
Aortic Valve Insufficiency
|
0.030 |
Biomarker
|
disease |
BEFREE |
However, survival rates, AVR, and development of late AI following BAV and SAV are equivalent.
|
31158809 |
2019 |
|
Atrial Fibrillation
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
In multivariable analysis, four parameters were associated with the AVR: aortic gradient (HR 1.52 [1.10-2.11], P = .012), LVEF (HR 0.58 [0.40-0.85], P = .006), atrial fibrillation (HR 0.43 [0.021-0.87], P = .019), and NT-proBNP (HR 0.92[0.86-0.98), P = .008].
|
31705575 |
2019 |
|
Irritable Bowel Syndrome
|
0.030 |
Biomarker
|
disease |
BEFREE |
Effect of mild moxibustion on intestinal microbiota and NLRP6 inflammasome signaling in rats with post-inflammatory irritable bowel syndrome.
|
31528095 |
2019 |
|
Irritable Bowel Syndrome
|
0.030 |
Biomarker
|
disease |
BEFREE |
CRF induces the NLRP6-inflammatory cytokine axis in IBS mice.
|
30663229 |
2019 |
|
Aortic Valve Insufficiency
|
0.030 |
Biomarker
|
disease |
BEFREE |
In conclusion, the congenitally BAV, unassociated with either infective endocarditis or aortic dissection, is a common cause of pure AR in adults in the Western World undergoing AVR for AR.
|
30343820 |
2018 |