DHFR, dihydrofolate reductase, 1719

N. diseases: 191; N. variants: 11
Disease: Tuberculosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.040 Biomarker disease BEFREE Here, structures of dihydrofolate reductase from M. tuberculosis (MtDHFR), which is a key target of the folate pathway, are reported in complex with four antifolates, pyrimethamine, cycloguanil, diaverdine and pemetrexed, and its substrate dihydrofolate in order to understand their binding modes. 31282477 2019
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.040 Biomarker disease BEFREE Expansion of a novel lead targeting M. tuberculosis DHFR as antitubercular agents. 30827867 2019
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.040 Biomarker disease BEFREE 2,4-diamino-1-phenyl-1,3,5-triazaspiro[5.5]undeca-2,4-dienes 20b and 20c were identified as selective M. tuberculosis DHFR inhibitors, showing promising antimycobacterial activities (MIC<sub>50</sub>: 0.01 μM and MIC<sub>90</sub>: 0.025 μM on M. tuberculosis H37Rv). 29274493 2018
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.040 Biomarker disease BEFREE We also prospectively identified novel inhibitors of dihydrofolate reductase with nanomolar antibacterial efficacy against Mycobacterium tuberculosis. 28806050 2017