DHODH, dihydroorotate dehydrogenase (quinone), 1723

N. diseases: 100; N. variants: 11
Disease: Schistosomiasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036323
Disease: Schistosomiasis
Schistosomiasis 		0.010 Biomarker disease BEFREE Well-known class 2 DHODH inhibitors were tested against SmDHODH and HsDHODH and the results suggest that the variable nature of the quinone-binding tunnel between human and parasite enzymes, as well as the differences in structural plasticity involving rearrangements of the N-terminal α-helical domain can be exploited for the design of SmDHODH selective inhibitors, as a strategy to validate DHODH as a drug target against schistosomiasis. 30664899 2019