|
Global developmental delay
|
0.400 |
Biomarker
|
disease |
HPO |
|
|
|
|
Global developmental delay
|
0.400 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development.
|
21850436 |
2012 |
|
Pica Disease
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Low set ears
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Byzanthine arch palate
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pneumocystis jirovecii ITS and DHPS genotypes were identified in 3 patient groups developing diverse forms of P. jirovecii infections: 13 patients with Pneumocystis pneumonia, 8 patients merely colonized by the fungus, and 19 immunocompetent infants with bronchiolitis developing mild P. jirovecii infection.
|
14736212 |
2003 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The dihydropteroate sulfate (DHPS) gene is associated with resistance to sulfa/sulfone drugs in Pneumocystis jirovecii.
|
25631478 |
2015 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Molecular analysis based on mtLSU-rRNA and DHPS sequences of Pneumocystis jirovecii from immunocompromised and immunocompetent patients in Italy.
|
23183313 |
2013 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study was performed to investigate mutations in the dihydropteroate synthase (DHPS) gene and their clinical consequences in HIV-infected patients with PCP.
|
30658203 |
2019 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Investigators have reported that patients infected with Pneumocystis carinii containing mutations in the DHPS (dihydropteroate synthase) gene have a worse outcome than those infected with P carinii containing wild-type DHPS.
|
11520525 |
2001 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, we have shown that mutations in the dihydropteroate synthase (DHPS) gene of Pneumocystis carinii f.sp hominis are associated with failure of sulpha prophylaxis and increased mortality in HIV-1 positive patients with PCP, suggesting that DHPS mutations may cause sulpha resistance.
|
11055650 |
2000 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the human-derived Pneumocystis carinii dihydropteroate synthase (DHPS) gene have been reported with increasing frequency and have been linked to prior sulfa prophylaxis and possible emergence of sulfa resistance.
|
11992293 |
2002 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pneumocystis jirovecii dihydropteroate synthase (DHPS) gene mutations are well-reported.
|
23470037 |
2013 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Dihydropteroate synthase (DHPS) gene mutation study in HIV-Infected Indian patients with Pneumocystis jirovecii pneumonia.
|
21252456 |
2010 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to determine whether the prevalence of Pneumocystis jirovecii dihydropteroate synthase (DHPS) gene mutations has changed since the introduction of combined antiretroviral therapy (cART) and whether the mutations are associated with poor outcome in Spanish HIV-1-infected patients with Pneumocystis pneumonia (PcP).
|
20727472 |
2010 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pneumocystis jirovecii dihydropteroate synthase (DHPS) gene mutations are associated with failure of sulfur prophylaxis of Pneumocystis pneumonia.
|
19085210 |
2009 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Especially with the long-term use of trimethoprim-sulfamethoxazole (TMP-SMX) and dapsone, certain point mutations in the Pneumocystis jirovecii (P. jirovecii) dihydropteroate synthase (DHPS) gene are known to play an important role in the development of resistance.
|
30027382 |
2018 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the phylogenetic and therapeutic implications of the genetic divergence in the dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) genes among different Pneumocystis carinii strains, these 2 genes in P. carinii obtained from 7 different host species were sequenced.
|
11679931 |
2001 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent studies of the human Pneumocystis carinii dihydropteroate synthase (DHPS) gene suggest that P. carinii is developing resistance to sulfamethoxazole (SMX) and dapsone.
|
10558954 |
1999 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Low prevalence of Pneumocystis pneumonia (PCP) but high prevalence of pneumocystis dihydropteroate synthase (dhps) gene mutations in HIV-infected persons in Uganda.
|
23166805 |
2012 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The CYB, DHFR, DHPS, mtLSU rRNA, SOD and the ITS loci are suitable genetic targets to be used in further epidemiological studies focused on the identification and characterization of P. jirovecii haplotypes correlated with drug resistance and PcP outcome.
|
20722602 |
2010 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pneumocystis jirovecii 23S mitochondrial large subunit of ribosomal RNA (23S mtLSU-rRNA), 26S rRNA, and dihydropteroate synthase (DHPS) genes were amplified by polymerase chain reaction (PCR), sequenced, and analysed for genetic variation.
|
29992629 |
2018 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Linking Pneumocystis jiroveci sulfamethoxazole resistance to the alleles of the DHPS gene using functional complementation in Saccharomyces cerevisiae.
|
19673964 |
2010 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Studies have consistently demonstrated a significant association between the use of sulfa drugs for PCP prophylaxis and DHPS gene mutations.
|
15504256 |
2004 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the prevalence of these mutations, a portion of P. jirovecii DHPS gene was analysed using PCR combined with restriction fragment length polymorphism (RFLP) analysis in 92 bronchoalveolar fluid samples collected between January 1998 and September 2001 from French patients with pulmonary pneumocystosis (PCP).
|
14725329 |
2003 |