|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pneumocystis jirovecii ITS and DHPS genotypes were identified in 3 patient groups developing diverse forms of P. jirovecii infections: 13 patients with Pneumocystis pneumonia, 8 patients merely colonized by the fungus, and 19 immunocompetent infants with bronchiolitis developing mild P. jirovecii infection.
|
14736212 |
2003 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study was performed to investigate mutations in the dihydropteroate synthase (DHPS) gene and their clinical consequences in HIV-infected patients with PCP.
|
30658203 |
2019 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Investigators have reported that patients infected with Pneumocystis carinii containing mutations in the DHPS (dihydropteroate synthase) gene have a worse outcome than those infected with P carinii containing wild-type DHPS.
|
11520525 |
2001 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, we have shown that mutations in the dihydropteroate synthase (DHPS) gene of Pneumocystis carinii f.sp hominis are associated with failure of sulpha prophylaxis and increased mortality in HIV-1 positive patients with PCP, suggesting that DHPS mutations may cause sulpha resistance.
|
11055650 |
2000 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the human-derived Pneumocystis carinii dihydropteroate synthase (DHPS) gene have been reported with increasing frequency and have been linked to prior sulfa prophylaxis and possible emergence of sulfa resistance.
|
11992293 |
2002 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pneumocystis jirovecii dihydropteroate synthase (DHPS) gene mutations are well-reported.
|
23470037 |
2013 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Dihydropteroate synthase (DHPS) gene mutation study in HIV-Infected Indian patients with Pneumocystis jirovecii pneumonia.
|
21252456 |
2010 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to determine whether the prevalence of Pneumocystis jirovecii dihydropteroate synthase (DHPS) gene mutations has changed since the introduction of combined antiretroviral therapy (cART) and whether the mutations are associated with poor outcome in Spanish HIV-1-infected patients with Pneumocystis pneumonia (PcP).
|
20727472 |
2010 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pneumocystis jirovecii dihydropteroate synthase (DHPS) gene mutations are associated with failure of sulfur prophylaxis of Pneumocystis pneumonia.
|
19085210 |
2009 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Especially with the long-term use of trimethoprim-sulfamethoxazole (TMP-SMX) and dapsone, certain point mutations in the Pneumocystis jirovecii (P. jirovecii) dihydropteroate synthase (DHPS) gene are known to play an important role in the development of resistance.
|
30027382 |
2018 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent studies of the human Pneumocystis carinii dihydropteroate synthase (DHPS) gene suggest that P. carinii is developing resistance to sulfamethoxazole (SMX) and dapsone.
|
10558954 |
1999 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Low prevalence of Pneumocystis pneumonia (PCP) but high prevalence of pneumocystis dihydropteroate synthase (dhps) gene mutations in HIV-infected persons in Uganda.
|
23166805 |
2012 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Linking Pneumocystis jiroveci sulfamethoxazole resistance to the alleles of the DHPS gene using functional complementation in Saccharomyces cerevisiae.
|
19673964 |
2010 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Studies have consistently demonstrated a significant association between the use of sulfa drugs for PCP prophylaxis and DHPS gene mutations.
|
15504256 |
2004 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the prevalence of these mutations, a portion of P. jirovecii DHPS gene was analysed using PCR combined with restriction fragment length polymorphism (RFLP) analysis in 92 bronchoalveolar fluid samples collected between January 1998 and September 2001 from French patients with pulmonary pneumocystosis (PCP).
|
14725329 |
2003 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate the possible association between different prophylactic sulfa drugs and the genotype of the Pneumocystis jiroveci dihydropteroate synthase (DHPS) gene, we examined DHPS polymorphisms in clinical specimens from 158 immunosuppressed patients (38 HIV-negative and 120 HIV-positive), using polymerase chain reaction-single-strand conformation polymorphism.
|
14513422 |
2003 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The impact of Pneumocystis jirovecii (formerly P. carinii) dihydropteroate synthase (DHPS) gene mutations on morbidity and mortality of Pneumocystis pneumonia (PCP) in HIV-positive patients is unclear.
|
15867494 |
2005 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since mutations in the dihydropteroate synthase (DHPS) gene possibly associated with sulfonamide resistance have been reported in patients with Pneumocystis jiroveci (previously carinii) pneumonia, and since P. jiroveci colonization has been recently demonstrated in patients with chronic pulmonary diseases, the present study aimed to investigate the possible occurrence of P. jiroveci DHPS mutations in patients with chronic bronchitis.
|
15175932 |
2004 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the dihydropteroate synthase (DHPS) gene of Pneumocystis jirovecii are associated with the failure of sulfa prophylaxis.
|
27855071 |
2017 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the genetic variation among isolates of Pneumocystis jiroveci from Portuguese immunocompromised patients with PCP at the internal transcribed spacer (ITS) regions of the nuclear rRNA operon and at the dihydropteroate synthase (DHPS) gene.
|
14636689 |
2003 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine factors associated with mutations in the Pneumocystis carinii dihydropteroate synthase (DHPS) gene, a prospective study of human immunodeficiency virus (HIV)-infected patients with confirmed P. carinii pneumonia was conducted in Atlanta, Seattle, and San Francisco.
|
10979917 |
2000 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We assessed whether mutations in the DHPS gene of P. carinii were associated with exposure to sulpha drugs and influenced outcome from PCP.
|
10533864 |
1999 |
|
Malaria
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
To assess N51I, C59R and S108N polymorphisms of dihydrofolate reductase (dhfr) and A437G and K540E of dihydropteroate synthase (dhps) genes of P. falciparum isolates recovered from pregnant women with asymptomatic malaria in a coastal setting in Nigeria.
|
26202938 |
2015 |
|
Malaria
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Population genetic study of Plasmodium falciparum parasites pertaining to dhps gene sequence in malaria endemic areas of Assam.
|
26068343 |
2016 |
|
Malaria
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
A study was carried out to assess the patterns of resistance and occurrence of DHFR/DHPS genotypes of Plasmodium falciparum prior to the adoption of sulfadoxine-pyrimethamine (SP) as first-line treatment for uncomplicated malaria in Tanzania.
|
15099990 |
2004 |