|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study was performed to investigate mutations in the dihydropteroate synthase (DHPS) gene and their clinical consequences in HIV-infected patients with PCP.
|
30658203 |
2019 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Especially with the long-term use of trimethoprim-sulfamethoxazole (TMP-SMX) and dapsone, certain point mutations in the Pneumocystis jirovecii (P. jirovecii) dihydropteroate synthase (DHPS) gene are known to play an important role in the development of resistance.
|
30027382 |
2018 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pneumocystis jirovecii 23S mitochondrial large subunit of ribosomal RNA (23S mtLSU-rRNA), 26S rRNA, and dihydropteroate synthase (DHPS) genes were amplified by polymerase chain reaction (PCR), sequenced, and analysed for genetic variation.
|
29992629 |
2018 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A transmission map was drawn up.P. jirovecii typing at DHPS, ITS and mtLSU rRNA sequences was performed in the patients of the cluster (18 patients with Pneumocystis pneumonia (PCP) and seven colonized patients), 10 unlinked control patients (six PCP patients and four colonized patients), as well as 23 other patients diagnosed with P. jirovecii (nine PCP patients and 14 colonized patients) in the same department over a three-year post-epidemic period.
|
28943270 |
2018 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the dihydropteroate synthase (DHPS) gene of Pneumocystis jirovecii are associated with the failure of sulfa prophylaxis.
|
27855071 |
2017 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The dihydropteroate sulfate (DHPS) gene is associated with resistance to sulfa/sulfone drugs in Pneumocystis jirovecii.
|
25631478 |
2015 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Molecular analysis based on mtLSU-rRNA and DHPS sequences of Pneumocystis jirovecii from immunocompromised and immunocompetent patients in Italy.
|
23183313 |
2013 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pneumocystis jirovecii dihydropteroate synthase (DHPS) gene mutations are well-reported.
|
23470037 |
2013 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Low prevalence of Pneumocystis pneumonia (PCP) but high prevalence of pneumocystis dihydropteroate synthase (dhps) gene mutations in HIV-infected persons in Uganda.
|
23166805 |
2012 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Dihydropteroate synthase (DHPS) gene mutation study in HIV-Infected Indian patients with Pneumocystis jirovecii pneumonia.
|
21252456 |
2010 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to determine whether the prevalence of Pneumocystis jirovecii dihydropteroate synthase (DHPS) gene mutations has changed since the introduction of combined antiretroviral therapy (cART) and whether the mutations are associated with poor outcome in Spanish HIV-1-infected patients with Pneumocystis pneumonia (PcP).
|
20727472 |
2010 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The CYB, DHFR, DHPS, mtLSU rRNA, SOD and the ITS loci are suitable genetic targets to be used in further epidemiological studies focused on the identification and characterization of P. jirovecii haplotypes correlated with drug resistance and PcP outcome.
|
20722602 |
2010 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Linking Pneumocystis jiroveci sulfamethoxazole resistance to the alleles of the DHPS gene using functional complementation in Saccharomyces cerevisiae.
|
19673964 |
2010 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pneumocystis jirovecii dihydropteroate synthase (DHPS) gene mutations are associated with failure of sulfur prophylaxis of Pneumocystis pneumonia.
|
19085210 |
2009 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The impact of Pneumocystis jirovecii (formerly P. carinii) dihydropteroate synthase (DHPS) gene mutations on morbidity and mortality of Pneumocystis pneumonia (PCP) in HIV-positive patients is unclear.
|
15867494 |
2005 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Studies have consistently demonstrated a significant association between the use of sulfa drugs for PCP prophylaxis and DHPS gene mutations.
|
15504256 |
2004 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since mutations in the dihydropteroate synthase (DHPS) gene possibly associated with sulfonamide resistance have been reported in patients with Pneumocystis jiroveci (previously carinii) pneumonia, and since P. jiroveci colonization has been recently demonstrated in patients with chronic pulmonary diseases, the present study aimed to investigate the possible occurrence of P. jiroveci DHPS mutations in patients with chronic bronchitis.
|
15175932 |
2004 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The P. jirovecii trifunctional DHNA-PPPK-DHPS genes (PjFAS) showed a high degree of conservation with the rat Pneumocystis carinii and P. carinii f. sp. macaca sequences.
|
15531210 |
2004 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pneumocystis jirovecii ITS and DHPS genotypes were identified in 3 patient groups developing diverse forms of P. jirovecii infections: 13 patients with Pneumocystis pneumonia, 8 patients merely colonized by the fungus, and 19 immunocompetent infants with bronchiolitis developing mild P. jirovecii infection.
|
14736212 |
2003 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the prevalence of these mutations, a portion of P. jirovecii DHPS gene was analysed using PCR combined with restriction fragment length polymorphism (RFLP) analysis in 92 bronchoalveolar fluid samples collected between January 1998 and September 2001 from French patients with pulmonary pneumocystosis (PCP).
|
14725329 |
2003 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate the possible association between different prophylactic sulfa drugs and the genotype of the Pneumocystis jiroveci dihydropteroate synthase (DHPS) gene, we examined DHPS polymorphisms in clinical specimens from 158 immunosuppressed patients (38 HIV-negative and 120 HIV-positive), using polymerase chain reaction-single-strand conformation polymorphism.
|
14513422 |
2003 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the genetic variation among isolates of Pneumocystis jiroveci from Portuguese immunocompromised patients with PCP at the internal transcribed spacer (ITS) regions of the nuclear rRNA operon and at the dihydropteroate synthase (DHPS) gene.
|
14636689 |
2003 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the human-derived Pneumocystis carinii dihydropteroate synthase (DHPS) gene have been reported with increasing frequency and have been linked to prior sulfa prophylaxis and possible emergence of sulfa resistance.
|
11992293 |
2002 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Investigators have reported that patients infected with Pneumocystis carinii containing mutations in the DHPS (dihydropteroate synthase) gene have a worse outcome than those infected with P carinii containing wild-type DHPS.
|
11520525 |
2001 |
|
Pneumocystis jiroveci pneumonia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the phylogenetic and therapeutic implications of the genetic divergence in the dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) genes among different Pneumocystis carinii strains, these 2 genes in P. carinii obtained from 7 different host species were sequenced.
|
11679931 |
2001 |