|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that the NQO1 609T allele is a high-penetrance risk factor for leukemia in Caucasians.
|
24175818 |
2013 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The NQO1 rs1800566 (C609T), PON1 rs854560 (L55M), and PON1 rs662 (Q192R) polymorphisms modified risk depending on leukemia subtype (decreased in AML, increased and decreased in ALL, respectively), age strata, and variant genotype combinations.
|
22976839 |
2012 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
We tested the hypothesis that LA affects the intracellular redox status and induces NQO1 expression using the human promyelocytic HL-60 leukemia cells.
|
18813798 |
2008 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The work studied possible association between genetic polymorphisms of CYP2D6, GSTM1, GSTT1and NQO1 and altered susceptibility to leukaemia, correlating these genetic polymorphisms with clinical prognostic data, response to therapy and relapse.
|
17581325 |
2007 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The most notable findings are: GSTM1 deletion and bladder cancer risk [odds ratio (OR) = 1.60; 95% confidence interval 1.00-2.56]; CYP1A1 and leukemia (2.22, 1.33-3.70; heterozygotes); CYP1B1 and leukemia (0.47, 0.27-0.84; homozygotes); MnSOD and leukemia (1.91, 1.08-3.38; homozygotes) and NQO1 and lung cancer (8.03, 1.73-37.3; homozygotes).
|
17496311 |
2007 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Excess transmission of the NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism in families of children with acute lymphoblastic leukemia.
|
17332311 |
2007 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The polymorphisms of CYP1A1, GSTM1, GSTP1, GSTT1 and NQO1 were not associated with the risk of leukaemia.
|
16284498 |
2005 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, low folate intake and compounds that are detoxified by NQO1 may be important in elevating leukemia risk in children.
|
15967214 |
2005 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In humans, a high percentage of individuals with myeloid and other types of leukemia are homo- and heterozygous for a null mutant allele of NQO1.
|
15935811 |
2005 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We demonstrated that the transcription factors E2F4, CTCF, NFATC3, and NFAT5, and the genes coding for NAD(P)H:quinone oxido-reductase 1 (NQO1) and for E-cadherin are not responsible for the leukemia susceptibility in these families.
|
15334552 |
2004 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The inactivating NQO1 polymorphism is associated with an increased risk of de novo leukemia with MLL translocations in infants and children.
|
12393620 |
2002 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A large epidemiologic investigation of a benzene-exposed population has shown that NQO1*2 homozygotes exhibit as much as a 7-fold greater risk of bone marrow toxicity, leading to diseases such as aplastic anemia and leukemia.
|
11882782 |
2002 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The inactivating NQO1 polymorphism is associated with an increased risk of de novo leukemia with MLL translocations in infants and children.
|
12393620 |
2002 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T was reportedly associated with leukemia, lung cancer, colorectal cancer, and urological malignancies.
|
12018106 |
2002 |