NQO1, NAD(P)H quinone dehydrogenase 1, 1728

N. diseases: 368; N. variants: 8
Disease: Adenoma of large intestine ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine 		0.050 GeneticVariation disease BEFREE Combination of the CYP1A1 2C and NQO1 609CC genotypes was associated with a decreased risk of colorectal adenomas regardless of smoking status. 23840148 2013
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine 		0.050 GeneticVariation disease BEFREE In contrast, Ser allele of NQO1 Ser187Pro might be a modest risk factor for CRA development [1.19 (1.06-1.33) and P ( z-test) = 0.003 for Ser carriers vs. Pro/Pro]. 22161138 2012
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine 		0.050 GeneticVariation disease BEFREE NQO1 187Ser allele was significantly associated with increased risk of colorectal adenoma in co-dominant and dominant comparison models (OR = 1.07, 95% CI = 1.04-1.32 for ProSer vs. ProPro and OR = 1.19, 95% CI = 1.06-1.33 for Ser carries vs. ProPro), without between-study heterogeneity. 22306249 2012
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine 		0.050 GeneticVariation disease BEFREE We investigated interactions between lifestyle factors and polymorphisms in NQO1 and its key regulatory transcription factor NFE2L2 in colorectal adenoma risk. 18074351 2008
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine 		0.050 GeneticVariation disease BEFREE In summary, joint carriage of CYP1A1 Val(462) and NQO1 Ser(187) alleles, particularly in smokers, was related to colorectal adenoma risk, with a propensity for formation of multiple lesions. 15731166 2005