NQO1, NAD(P)H quinone dehydrogenase 1, 1728

N. diseases: 368; N. variants: 8
Disease: Mammary Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.390 Biomarker group BEFREE Additionally, high levels of expression of Nrf2, ABCC1, ABCC3 plus NAD(P)H dehydrogenase quinone-1 in breast tumors of patients at the time of diagnosis were prognostic of poor survival after tamoxifen therapy. 26883574 2016
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.390 AlteredExpression group BEFREE Thus, the NQO1 gene copy number and NQO1 activity should be considered when quinone-bearing molecules are being utilized as potential drugs against breast tumors. 26687450 2016
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.390 AlteredExpression group BEFREE NQO1 and nuclear NFκB were expressed in 83% and 11% of breast tumors, and correlated inversely (P = 0.012). 21706157 2012
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.390 Biomarker group LHGDN Resveratrol prevents estrogen-DNA adduct formation and neoplastic transformation in MCF-10F cells. 19138946 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.390 Biomarker group CTD_human We propose a model of defective anthracycline response in NQO1-deficient breast tumors, along with increased genomic instability promoted by elevated reactive oxygen species (ROS), and suggest that the NQO1 genotype is a prognostic and predictive marker for breast cancer. 18511948 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.390 Biomarker group BEFREE We propose a model of defective anthracycline response in NQO1-deficient breast tumors, along with increased genomic instability promoted by elevated reactive oxygen species (ROS), and suggest that the NQO1 genotype is a prognostic and predictive marker for breast cancer. 18511948 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.390 GeneticVariation group LHGDN We propose a model of defective anthracycline response in NQO1-deficient breast tumors, along with increased genomic instability promoted by elevated reactive oxygen species (ROS), and suggest that the NQO1 genotype is a prognostic and predictive marker for breast cancer. 18511948 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.390 AlteredExpression group BEFREE Immunohistochemical analysis of 354 invasive breast tumors revealed that NQO1 protein expression in a subset of breast tumors is higher than in normal epithelium, which contradicts its proposed role as a tumor suppressor gene.ATBF1 has been suggested as a target for LOH at 16q in prostate cancer. 18416817 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.390 GeneticVariation group LHGDN Genetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer. 17726138 2007
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.390 GeneticVariation group LHGDN Oral contraceptive use and breast cancer risk: modification by NAD(P)H:quinone oxoreductase (NQO1) genetic polymorphisms. 15298951 2004
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.390 Biomarker group BEFREE NQO1 results suggest that different quinones (possibly estrogenic quinone metabolites) might affect the histological development of breast tumors. 11810042 2002