|
Thyroid Gland Follicular Adenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
It accounts for the robust response of the 6.8-kb hdio2 5'-FR to protein kinase A. Forskolin increases D2 mRNA in human thyroid cells, which may explain the high D2 mRNA in Graves' thyroid and thyroid adenomas.
|
10614643 |
2000 |
|
Brain Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Expression of type II iodothyronine deiodinase in brain tumors.
|
11095486 |
2000 |
|
Mesothelioma
|
0.300 |
Biomarker
|
disease |
CTD_human |
An antiserum prepared against a peptide deduced from the Dio2 mRNA sequence precipitates a (75)Se protein of the predicted 31-kDa size from (75)Se-labeled mesothelioma cells.
|
11425850 |
2001 |
|
Obesity
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
We performed molecular scanning of the human type 2 deiodinase (DIO2) gene and evaluated a novel variant for associations with obesity and insulin resistance, assessing both the main effect and interaction with the Trp64Arg beta-3--adrenergic receptor (ADRB3) variant.
|
11872697 |
2002 |
|
Pituitary Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Expression of 5'-deiodinase enzymes in normal pituitaries and in various human pituitary adenomas.
|
12153750 |
2002 |
|
Intellectual Disability
|
0.030 |
GeneticVariation
|
group |
BEFREE |
We conclude that allelic variation in the DIO2 gene may affect the amount of T3 available and in an iodine-deficient environment may partly determine overall risk of MR.
|
15286152 |
2004 |
|
Intellectual Disability
|
0.030 |
GeneticVariation
|
group |
LHGDN |
We conclude that allelic variation in the DIO2 gene may affect the amount of T3 available and in an iodine-deficient environment may partly determine overall risk of MR.
|
15286152 |
2004 |
|
Mental Retardation
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We conclude that allelic variation in the DIO2 gene may affect the amount of T3 available and in an iodine-deficient environment may partly determine overall risk of MR.
|
15286152 |
2004 |
|
Choriocarcinoma
|
0.010 |
Biomarker
|
disease |
LHGDN |
Functional characterisation of the CRE/TATA box unit of type 2 deiodinase gene promoter in a human choriocarcinoma cell line.
|
15291742 |
2004 |
|
Graves Disease
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
This suggests that the Thr92Ala variant of the DIO2 gene is associated or may be in linkage disequilibrium with a functional DIO2 polymorphism which involves in the development of GD in a Russian population.
|
15542398 |
2004 |
|
Papillary thyroid carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
DIO1 and DIO2 were underexpressed in nearly all papillary thyroid carcinomas.
|
15785240 |
2005 |
|
Thyroid Neoplasm
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Gene expression profiles reveal that DCN, DIO1, and DIO2 are underexpressed in benign and malignant thyroid tumors.
|
15785240 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
LHGDN |
The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.
|
15797963 |
2005 |
|
Endemic Cretinism
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the previous study, we have proposed that DIO2 may protect against FIDD in the iodine-deficient areas of China.
|
15911145 |
2005 |
|
Follicular thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Type II iodothyronine deiodinase (D2) activity was also significantly higher in metastatic FTC samples than in normal thyroid tissues (5.20 +/- 0.81 vs. 0.30 +/- 0.27 fmol T4/min/mg protein, P < 0.001).
|
15943828 |
2005 |
|
Euthyroid Sick Syndromes
|
0.010 |
Biomarker
|
disease |
LHGDN |
Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans.
|
16127464 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
No association was found among the Thr92Ala DIO2 variant and type 2 diabetes, impaired glucose tolerance, or body mass index (BMI) in the Amish.
|
16356084 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
The DIO2 Thr92Ala variant does not confer an increased risk of T2D, obesity, or insulin resistance.
|
17077128 |
2007 |
|
Obesity
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
We detected no significant association of the DIO2 Thr92Ala polymorphism with T2D or obesity.
|
17077128 |
2007 |
|
Alzheimer's Disease
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association of recently identified polymorphisms in the DIO1 (D1a-C/T, D1b-A/G) and DIO2 (D2-ORFa-Gly3Asp, D2-Thr92Ala) genes with circulating thyroid parameters and early neuroimaging markers of AD.
|
17105838 |
2007 |
|
Hypertensive disease
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Among euthyroid adults, the common Ala92 allele of the type 2 iodothyronine deiodinase increases risk for the development of hypertension.
|
17224473 |
2007 |
|
Hypertensive disease
|
0.030 |
GeneticVariation
|
group |
LHGDN |
Among euthyroid adults, the common Ala92 allele of the type 2 iodothyronine deiodinase increases risk for the development of hypertension.
|
17224473 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism in DIO2 gene (A/G) in humans has been associated with a approximately 20% lower glucose disposal rate and greater insulin resistance in type 2 diabetes (DM2) patients.
|
17381351 |
2007 |
|
Diabetes Mellitus
|
0.020 |
GeneticVariation
|
group |
BEFREE |
This study was designed to test whether homozygosity for the DIO2 A/G polymorphism would be associated with risk of DM2 or elevated levels of diabetes intermediate traits.
|
17381351 |
2007 |
|
Dystrophia myotonica 2
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
This study was designed to test whether homozygosity for the DIO2 A/G polymorphism would be associated with risk of DM2 or elevated levels of diabetes intermediate traits.
|
17381351 |
2007 |