|
Thyroid Diseases
|
0.310 |
Biomarker
|
group |
BEFREE |
Functional Polymorphisms of the Type 1 and Type 2 Iodothyronine Deiodinase Genes in Autoimmune Thyroid Diseases.
|
29648895 |
2018 |
|
Thyroid Diseases
|
0.310 |
Biomarker
|
group |
CTD_human |
Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells.
|
23397585 |
2013 |
|
Bipolar Disorder
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
We hypothesize that genetic variations in the type II deiodinase (DIO2) gene that possibly alter the bioactivity of thyroid hormones are associated with BPAD.
|
19427350 |
2009 |
|
Bipolar Disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
We hypothesize that genetic variations in the type II deiodinase (DIO2) gene that possibly alter the bioactivity of thyroid hormones are associated with BPAD.
|
19427350 |
2009 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
CTD_human |
Disrupted brain thyroid hormone homeostasis and altered thyroid hormone-dependent brain gene expression in autism spectrum disorders.
|
24781735 |
2014 |
|
Endometriosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Molecular evidence for differences in endometrium in severe versus mild endometriosis.
|
21063030 |
2011 |
|
Endometrioma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Molecular evidence for differences in endometrium in severe versus mild endometriosis.
|
21063030 |
2011 |
|
Mesothelioma
|
0.300 |
Biomarker
|
disease |
CTD_human |
An antiserum prepared against a peptide deduced from the Dio2 mRNA sequence precipitates a (75)Se protein of the predicted 31-kDa size from (75)Se-labeled mesothelioma cells.
|
11425850 |
2001 |
|
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the male fish, transcriptions of corticotropin-releasing hormone (crh) and thyroid-stimulating hormone (tsh) in the brain were significantly up-regulated, probably as a compensation for hypothyroidism, but thyroglobulin (tg) and deiodinase 2 (dio2) were down-regulated in thyroid or liver.
|
30508752 |
2019 |
|
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that D2 loss leads to significant changes in soleus contractile function and fiber type composition that are inconsistent with local hypothyroidism and suggest that reduced levels of PCG-1α may contribute to the observed phenotypical changes.
|
30951174 |
2019 |
|
Hypothyroidism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, it was observed that the pituitary content of Dio2 mRNA was unaltered in hyperthyroidism but substantially elevated in hypothyroidism during the light phase.
|
30747053 |
2019 |
|
Hypothyroidism
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An Ala92-Dio2 polymorphism-carrying mouse exhibited UPR and hypothyroidism in distinct brain areas.
|
30352046 |
2019 |
|
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Homozygous Dio2-deficient zebrafish were hypothyroid, displayed a delay in sexual maturity, and the duration of their reproductive period was substantially shortened.
|
30817317 |
2019 |
|
Hypothyroidism
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
One hypothesis is that a SNP (Thr92Ala) in DIO2 (required for local production of T3 out of T4) interferes with its kinetics and/or action, resulting in a local hypothyroid state in the brain.
|
31617166 |
2019 |
|
Hypothyroidism
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A new report indicates that carriers of the Thr92Ala-DIO2 polymorphism exhibit lower D2 catalytic activity and localized/systemic hypothyroidism.
|
30063552 |
2018 |
|
Thyroxine measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.
|
30367059 |
2018 |
|
Hypothyroidism
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, residual symptoms of hypothyroidism have been linked to a prevalent polymorphism in the DIO2 gene that might be a risk factor for neurodegenerative disease.
|
26416219 |
2015 |
|
Hypothyroidism
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study investigates the clinical and biochemical response to L-T4 replacement therapy in hypothyroid patients in correlation with genetic variation in Deiodinase type ;; (DIO2) gene.
|
23329579 |
2013 |
|
Hypothyroidism
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism (Thr92Ala) in the gene encoding the deiodinase 2 (D2) enzyme that converts thyroxine to triiodothyronine in the brain was later identified in about 16% of hypothyroid persons.
|
22548953 |
2013 |
|
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Type 2 iodothyronine deiodinase in skeletal muscle: effects of hypothyroidism and fasting.
|
19293265 |
2009 |
|
Hypothyroidism
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients.
|
19190113 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Moreover, inactivating mutations in type 2 deiodinase (DIO2), the major TH-activating enzyme, have been associated with type 2 diabetes mellitus in both humans and mice.
|
31504428 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Homozygosity for the Dio2 Thr92Ala polymorphism is associated with higher HbA1C levels in T2DM patients.
|
27777960 |
2016 |
|
Degenerative polyarthritis
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Our findings show how genetic variation at DIO2 could confer risk to OA and raised the possibility that counteracting thyroid signalling may be a novel therapeutic approach.
|
24695009 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
The entire coding-region of DIO2 gene was sequenced in 12 patients with type 2 diabetes mellitus (T2DM).
|
25105294 |
2014 |