DIO2, iodothyronine deiodinase 2, 1734

N. diseases: 79; N. variants: 10
Disease: Osteoarthritis of hip ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.020 GeneticVariation disease BEFREE We observed a significant interaction between carrier status of DIO2 rs12885300 and hip OA characteristics for mode 1 (P = 0.005). 21400473 2011
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.020 GeneticVariation disease BEFREE Confirmation and replication by association in the additional osteoarthritis studies indicated a common DIO2 haplotype, exclusively containing the minor allele of rs225014 and common allele of rs12885300, with a combined recessive odds ratio of 1.79, 95% confidence interval (CI) 1.37-2.34 with P = 2.02 x 10(-5) in female cases with advanced/symptomatic hip osteoarthritis. 18334578 2008