DIO2, iodothyronine deiodinase 2, 1734

N. diseases: 79; N. variants: 10
Disease: Metabolic Syndrome X ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.020 GeneticVariation disease BEFREE In both groups, the D2-Thr92Ala polymorphism was not associated with differences in TSH, fT4, fT3, the fT3/fT4 ratio, presence of metabolic syndrome or other comorbidities, use of medication, HRQoL, and cognitive functioning. 27786042 2017
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.020 GeneticVariation disease BEFREE A significant gene-gene interaction was observed in the modulation of systolic (p = 0.01) and diastolic (p = 0.02) blood pressure and metabolic syndrome (p = 0.02), with carriers of both DIO2 A92 and PPARgamma2 A12 variants showing the worst phenotype. 18198294 2007