DIO2, iodothyronine deiodinase 2, 1734

N. diseases: 79; N. variants: 10
Disease: Kashin-Beck Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2745963
Disease: Kashin-Beck Disease
Kashin-Beck Disease 		0.040 Biomarker disease BEFREE Therefore, it is necessary to explore the association between KBD and DIO2 in the Tibetan population. 31433532 2019
CUI: C2745963
Disease: Kashin-Beck Disease
Kashin-Beck Disease 		0.040 GeneticVariation disease BEFREE The meta-analysis of the GPX1 rs1050450, DIO2 rs225014, TrxR2 rs5748469 and HLA-DRB1 rs7745040 failed to reveal any associations with KBD. 27256326 2016
CUI: C2745963
Disease: Kashin-Beck Disease
Kashin-Beck Disease 		0.040 AlteredExpression disease BEFREE In addition, bone development-related genes GDF5 (expression ratio = 2.14±0.02) and DIO2 (expression ratio = 0.11±0.05) may contribute to the development of KBD in children rather than in adults. 25072641 2014
CUI: C2745963
Disease: Kashin-Beck Disease
Kashin-Beck Disease 		0.040 GeneticVariation disease BEFREE To investigate the association of the selenoprotein genes GPX1 (rs1050450, rs1800668, and rs3811699), TrxR2 (rs5748469), and DIO2 (rs225014) with Kashin-Beck disease (KBD) in a Tibetan population and to investigate the association of these SNPs with the serum iodine/selenium concentration in the Tibetan population. 24058403 2013