DIO3, iodothyronine deiodinase 3, 1735

N. diseases: 80; N. variants: 1
Disease: Abnormal behavior ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.020 AlteredExpression phenotype BEFREE Constitutive loss of the type 3 deiodinase (DIO3) causes abnormally increased levels of thyroid hormone action in the developing and adult brain, leading to an array of behavioral abnormalities. 31561084 2019
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.020 Biomarker phenotype BEFREE DIO3 deficiency in mice results in a host of neurodevelopmental and behavioral abnormalities, demonstrating the deleterious effects of TH excess, and revealing the critical role of DIO3 in the regulation of TH action in the brain. 29921775 2018