|
Papillary thyroid carcinoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
Down-regulation of 14q32-encoded miRNAs and tumor suppressor role for miR-654-3p in papillary thyroid cancer.
|
28030816 |
2017 |
|
Neoplasm Metastasis
|
0.320 |
Biomarker
|
phenotype |
CTD_human |
MAPK and SHH pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma.
|
26825960 |
2016 |
|
Papillary thyroid carcinoma
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Similarly, DIO3 mRNA levels were higher in PTC samples harboring the BRAF(V600E) mutation as compared with those with RET/PTC1 rearrangement or negative for these mutations (P<0.001).
|
26825960 |
2016 |
|
Neoplasm Metastasis
|
0.320 |
Biomarker
|
phenotype |
BEFREE |
DLK1-DIO3 cluster miRNAs are elevated in the serum of patients with metastatic cancer.
|
25324143 |
2014 |
|
Neoplasm Metastasis
|
0.320 |
Biomarker
|
phenotype |
BEFREE |
These results establish the DLKI-DIO3 miRNA cluster as a critical checkpoint regulating tumor growth and metastasis and implicate epigenetic modification of the cluster in driving tumor progression.
|
23105110 |
2012 |
|
Papillary thyroid carcinoma
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Studies of DIO3 gene regulation were performed in a human PTC-derived cell line (K1 cells).
|
22823995 |
2012 |
|
Malignant neoplasm of breast
|
0.310 |
Biomarker
|
disease |
BEFREE |
Pathways related to EMT and TGF-beta reinforce the relevance of miR-200, miR-199 and DLK1-DIO3 cluster in breast cancer.
|
29051564 |
2017 |
|
Breast Carcinoma
|
0.310 |
Biomarker
|
disease |
BEFREE |
Pathways related to EMT and TGF-beta reinforce the relevance of miR-200, miR-199 and DLK1-DIO3 cluster in breast cancer.
|
29051564 |
2017 |
|
Malignant neoplasm of breast
|
0.310 |
Biomarker
|
disease |
CTD_human |
Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K.
|
25330770 |
2014 |
|
Breast Carcinoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K.
|
25330770 |
2014 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells.
|
21727898 |
2012 |
|
Schizophrenia
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells.
|
21727898 |
2012 |
|
Nonmedullary Thyroid Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Down-regulation of 14q32-encoded miRNAs and tumor suppressor role for miR-654-3p in papillary thyroid cancer.
|
28030816 |
2017 |
|
Familial Nonmedullary Thyroid Cancer
|
0.300 |
Biomarker
|
disease |
CTD_human |
Down-regulation of 14q32-encoded miRNAs and tumor suppressor role for miR-654-3p in papillary thyroid cancer.
|
28030816 |
2017 |
|
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K.
|
25330770 |
2014 |
|
Mammary Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K.
|
25330770 |
2014 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
CTD_human |
Disrupted brain thyroid hormone homeostasis and altered thyroid hormone-dependent brain gene expression in autism spectrum disorders.
|
24781735 |
2014 |
|
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K.
|
25330770 |
2014 |
|
Heart failure
|
0.200 |
Biomarker
|
disease |
RGD |
Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats.
|
18259611 |
2008 |
|
Congestive heart failure
|
0.200 |
Biomarker
|
disease |
RGD |
Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats.
|
18259611 |
2008 |
|
Neoplasms
|
0.090 |
GeneticVariation
|
group |
BEFREE |
We discovered that Snail mediated the downregulation of the imprinted Dlk1-Dio3 locus, a complex genomic region containing protein-coding genes and non-coding RNAs that has been linked to tumor malignancy in lung cancer patients.
|
30190790 |
2018 |
|
Neoplasms
|
0.090 |
GeneticVariation
|
group |
BEFREE |
The cluster of microRNAs (miRNAs) in the DLK1-DIO3 genomic imprinted region contains several miRNAs that have a significant regulatory role in tumor proliferation and invasion.
|
28043921 |
2017 |
|
Neoplasms
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Further, a large number of miRs observed in tumour network mapped to a specific chromosomal location in DLK1-DIO3 (Chr14q32); some of those miRs have also been associated with EMT and MET regulation.
|
29051564 |
2017 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Type 3 deiodinase (DIO3, D3) is reactivated in human neoplasias.
|
26825960 |
2016 |
|
Neoplasms
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Moreover, the high BCL-xL expression correlated with short treatment-free survival in 76 CLL patients. miR-377 is located at 14q32 in the DLK1-DIO3 region, which encodes the largest tumor suppressor miRNA cluster in humans.
|
26537004 |
2015 |