|
Schizophrenia
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.
|
30285260 |
2019 |
|
Schizophrenia
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
Based on conjunctional FDR < 0.05, we identified 2 loci shared between SCZ and ICV implicating genes FOXO3 (rs10457180) and ITIH4 (rs4687658), 2 loci shared between SCZ and hippocampal volume implicating SLC4A10 (rs4664442) and SPATS2L (rs1653290), and 2 loci shared between SCZ and volume of putamen implicating DCC (rs4632195) and DLG2 (rs11233632).
|
29136250 |
2018 |
|
Schizophrenia
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia.
|
28991256 |
2017 |
|
Schizophrenia
|
0.460 |
Biomarker
|
disease |
BEFREE |
To identify markers of disks, large homolog 2 (DLG2), FAT atypical cadherin 3 (FAT3), kinectin1 (KTN1), deleted in colorectal carcinoma (DCC), and glycogen synthase kinase-3β (GSK3β) that contribute to the genetic susceptibility to schizophrenia, we systematically screened for polymorphisms in the functional regions of these genes.
|
27055860 |
2016 |
|
Schizophrenia
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of schizophrenia in Ashkenazi Jews.
|
26198764 |
2015 |
|
Schizophrenia
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
We then explored whether the human orthologs of these genes are associated with schizophrenia in the largest schizophrenia genome-wide association study published to date, and found evidence for association for 4 out of the 20 genes: SF3B1, FOXP1, DLG2 and VGLL4.
|
26460480 |
2015 |
|
Schizophrenia
|
0.460 |
Biomarker
|
disease |
PSYGENET |
Using this system we focused on three postsynaptic proteins DISC1, TNIK and PSD-93/DLG2 each of which is encoded by a schizophrenia susceptibility gene.
|
21440632 |
2011 |
|
Schizophrenia
|
0.460 |
Biomarker
|
disease |
BEFREE |
Using this system we focused on three postsynaptic proteins DISC1, TNIK and PSD-93/DLG2 each of which is encoded by a schizophrenia susceptibility gene.
|
21440632 |
2011 |
|
Schizophrenia
|
0.460 |
Biomarker
|
disease |
PSYGENET |
We found significant changes in the expression of NF-L in DLPFC, and PSD-95 and PSD-93 in ACC; increased transcript expression was associated with decreased protein expression, suggesting abnormal translation and/or accelerated protein degradation of these molecules in schizophrenia.
|
16702973 |
2006 |
|
Schizophrenia
|
0.460 |
AlteredExpression
|
disease |
BEFREE |
We found significant changes in the expression of NF-L in DLPFC, and PSD-95 and PSD-93 in ACC; increased transcript expression was associated with decreased protein expression, suggesting abnormal translation and/or accelerated protein degradation of these molecules in schizophrenia.
|
16702973 |
2006 |
|
Schizophrenia
|
0.460 |
Biomarker
|
disease |
PSYGENET |
We found decreased striatal expression of transcripts encoding PSD-95 and SAP-102 in bipolar disorder and of SAP-102 in major depression and schizophrenia, while no significant changes in NF--L and PSD-93 mRNAs were observed.
|
16023328 |
2005 |
|
Schizophrenia
|
0.460 |
Biomarker
|
disease |
BEFREE |
These results suggest that PSZA11q14 may be considered a candidate gene for schizophrenia acting as an antisense regulator of DLG-2, which controls assembling functional N-methyl-D-aspartate (NMDA) receptors.
|
13130513 |
2003 |
|
Schizophrenia
|
0.460 |
Biomarker
|
disease |
PSYGENET |
These results suggest that PSZA11q14 may be considered a candidate gene for schizophrenia acting as an antisense regulator of DLG-2, which controls assembling functional N-methyl-D-aspartate (NMDA) receptors.
|
13130513 |
2003 |