DLX3, distal-less homeobox 3, 1747

N. diseases: 67; N. variants: 5
Disease: Epithelial hyperplasia of skin ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0263641
Disease: Epithelial hyperplasia of skin
Epithelial hyperplasia of skin 		0.020 Biomarker disease BEFREE Epidermis lacking DLX3 (DLX3cKO), which is linked to the development of a DLX3-dependent epidermal hyperplasia with hyperkeratosis and dermal leukocyte recruitment, displays enhanced PKCα activation, suggesting a feedback regulation of DLX3 and PKCα. 28186503 2017
CUI: C0263641
Disease: Epithelial hyperplasia of skin
Epithelial hyperplasia of skin 		0.020 Biomarker disease BEFREE Here we report on a novel DLX3-dependent network that constrains epidermal hyperplasia and squamous tumorigenesis. 26522723 2016