|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among subjects with spine fracture, 26 % met BMD criteria for osteoporosis.
|
28175980 |
2017 |
|
Osteoporosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Aiming to identify genomic loci associated with BMD variation at TRO and INT regions, we performed a GWAS utilizing the Framingham Heart Study (FHS, N = 6,912) as discovery sample and utilized the Women's Health Initiative (WHI) African-American subsample (N = 845), WHI Hispanic subsample (N = 446), and Omaha osteoporosis study (N = 971), for replication.
|
27311723 |
2016 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
FN_BMD is an important risk factor for osteoporosis.
|
30172742 |
2018 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the performance of OSTA is influenced by age, sex, ethnicity and site of BMD measurement to define osteoporosis.
|
28695762 |
2017 |
|
Osteoporosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The objectives of this study are to assess the correlation between BMD and serum lipid levels, to determine independent variables associated with osteoporosis and osteopenia in men and postmenopausal women with type 2 diabetes (T2D).
|
30235494 |
2019 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the majority of individuals who have low-trauma fractures do not have osteoporosis with DXA (i.e., T-score <-2.5), and some of them have no decreased BMD at all.
|
28161747 |
2017 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The estimated BMD testing interval for 10 % of patients to develop osteoporosis was 9.6 years for those with normal BMD, 7.6 years for those with mild osteopenia, 4.7 years for those with moderate osteopenia, and 2.1 years for those with severe osteopenia.
|
27509834 |
2017 |
|
Osteoporosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The effects of icariin on various genes were detected by PCR and Western blot methods The correction between the expression of PPARγ and BMD was analyzed in patients with osteoporosis.
|
28122309 |
2017 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Levels of hydroxyproline, Gly-Gly and cystine, differed significantly between groups, with Gly-Gly and cystine significantly lower in the low BMD group and hydroxyproline, a reported marker of osteoporosis, significantly higher.
|
27989648 |
2017 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Any observational study, which tested the association between VDR BsmI genotypes and either BMD or osteoporosis at the femoral neck or spine in adult women, was included in the review.
|
15040830 |
2004 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The new diagnostic criteria continue to include a T-score by DXA of spine or hip that is less than or equal to -2.5, but alternatively also include a hip fracture with or without BMD testing or a vertebral, pelvis, proximal humerus and in some cases a distal forearm fracture in a person with low bone mass, or a FRAX score that meets or exceeds the NOF Guide osteoporosis treatment cut point.
|
28936598 |
2017 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we performed BMD measurement combined with vertebral fracture assessment (VFA) by DXA for the postmenopausal women receiving the first bone densitometry and studied the impact of VFA on the diagnosis of osteoporosis.
|
31352490 |
2020 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Administrative health claims data were used to determine monthly rates of BMD testing and initiation of osteoporosis medicines in the 9-months post-intervention among targeted men and women compared to older cohorts of men and women.
|
28188561 |
2017 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The diagnosis of osteoporosis is intimately linked with the imaging and quantification of bone and BMD.
|
31189982 |
2019 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of our study is to examine the association between LTL, and BMD and osteoporosis among an elderly Chinese population.
|
31025211 |
2019 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using whole blood DNA methylation analysis, women at risk of developing osteoporosis can be identified before a diagnosis of osteoporosis is made using BMD as a screening method.
|
29924424 |
2018 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, we describe a novel method to correct the crosstalk effect in pathway analysis and found five key independent pathways involved in BMD regulation, which may provide a better understanding of biological functional networks in osteoporosis.
|
29330445 |
2018 |
|
Osteoporosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The only quality improvement strategy for which meta-analysis findings demonstrated significant improvement of osteoporosis care for patient populations including individuals without prior fracture was patient self-scheduling of DXA plus education, for increasing the outcome of BMD testing (risk difference 13%, 95% CI 7%-18%).
|
29637658 |
2018 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Those who took osteoporosis medication during the observation study showed a smaller decline in BMD than those who did not.No new safety concerns were identified.
|
28144701 |
2017 |
|
Osteoporosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In women with osteoporosis and osteopenia homozygous AA genotype may predispose to lower BMD in the lumbar spine.
|
25980946 |
2015 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This prospective study examined the effects of once-weekly teriparatide treatment on the serum levels of sclerostin, osteocalcin, and bone formation markers as well as BMD of the lumbar spine and femoral neck in 32 postmenopausal women with osteoporosis.
|
30573396 |
2019 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients who elected to discontinue osteoporosis treatment experienced a significant decline in the change in BMD compared to the change on teriparatide putting them at higher risk for recurrence of fragility fractures.
|
29541794 |
2018 |
|
Osteoporosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Quantitative trait loci for BMD identified by autosome-wide linkage scan to chromosomes 7q and 21q in men from the Amish Family Osteoporosis Study.
|
16939402 |
2006 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In particular, four out of six most significant pathways identified by the uHDSet but missed by famSKAT have been reported to be related to BMD or osteoporosis in the literature.
|
26458888 |
2016 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Peak BMD is an important predictor of future risk of osteoporosis and is largely determined by genetic factors but also by environmental factors, among which physical activity (PA) is a strong contributor.
|
17451372 |
2007 |