|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Osteoporosis is a disease characterized by the deterioration of bone tissue and the consequent decrease in BMD and increase in bone fragility.
|
28265896 |
2017 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Osteoporosis in all skeletal sites significantly related to increased risk of mortality in men and women, but the associations were stronger for BMD in the femur neck and total hip than in the lumbar spine.
|
30660675 |
2019 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
BMD is a primary predictor of osteoporotic fracture and a key phenotype for the genetic study of osteoporosis.
|
15125790 |
2004 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
BMD is a heritable trait and risk indicator for osteoporosis.
|
19113921 |
2009 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
BMD (classified according to the WHO criteria for osteoporosis) of the hip and lumbar spine, the VFx (classified as a Genant score >1/>20% height loss), and radiological progression (modified stoke ankylosing spondylitis spinal score [mSASSS]) scores were obtained at baseline and at 4 years of TNFi treatment.Overall, 135 AS patients were included.
|
30690799 |
2019 |
|
Osteoporosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BMD measurements and kidney function for risk prediction were also evaluated; women were categorized by both reduced kidney function (stages 3-5) and osteoporosis status.
|
31754754 |
2020 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A major determinant of osteoporosis is peak BMD, which is a highly heritable trait.
|
16598376 |
2006 |
|
Osteoporosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A number of studies investigated the distribution of BMD values and the prevalence of osteoporosis in China, but their findings varied.
|
31067339 |
2019 |
|
Osteoporosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A once-weekly pill containing risedronate and cholecalciferol had the equivalent antiresorptive efficacy on BMD compared with risedronate alone and improved 25(OH) D serum levels after 12 months of treatment without significant adverse events in Korean patients with osteoporosis.
|
31820121 |
2019 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A total 24 texture features demonstrated statistically significant differences between normal BMD and osteoporosis in the left sphenoid and a total of 31 texture features in the left condyle.
|
31153568 |
2019 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Administrative health claims data were used to determine monthly rates of BMD testing and initiation of osteoporosis medicines in the 9-months post-intervention among targeted men and women compared to older cohorts of men and women.
|
28188561 |
2017 |
|
Osteoporosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Aiming to identify genomic loci associated with BMD variation at TRO and INT regions, we performed a GWAS utilizing the Framingham Heart Study (FHS, N = 6,912) as discovery sample and utilized the Women's Health Initiative (WHI) African-American subsample (N = 845), WHI Hispanic subsample (N = 446), and Omaha osteoporosis study (N = 971), for replication.
|
27311723 |
2016 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altogether, 126 postmenopausal women belonging to four different groups were included: healthy (n=42), low BMD and no vertebral fractures (n=39), vertebral fractures and low BMD without a treatment (n=26), or receiving a treatment for osteoporosis (n=19).
|
31669252 |
2020 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among subjects with spine fracture, 26 % met BMD criteria for osteoporosis.
|
28175980 |
2017 |
|
Osteoporosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
And the rs12218 was found to be associated with plasma TG, HDL-C, LDL-C, and BMD levels in osteoporosis patients (P<0.05).
|
23522429 |
2013 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Any observational study, which tested the association between VDR BsmI genotypes and either BMD or osteoporosis at the femoral neck or spine in adult women, was included in the review.
|
15040830 |
2004 |
|
Osteoporosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Are effects of MTHFR (C677T) genotype on BMD confined to women with low folate and riboflavin intake? Analysis of food records from the Danish osteoporosis prevention study.
|
15777680 |
2005 |
|
Osteoporosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As he continued to run over the following 2 years, his mileage threshold to fracture steadily and rapidly decreased until he was diagnosed with severe osteoporosis (lumbar spine BMD Z-score of -3.2).
|
30972028 |
2019 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Combination or sequential therapies of boneforming agents and anti-resorptive agents, or two kinds of anti-resorptive agents, or strontium ranelate and other anti-osteoporosis agents have the advantages on BMD compared with monotherapy.
|
28521691 |
2017 |
|
Osteoporosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Data from human diseases or dysfunctions identified 19 genes whose mutation was associated with human BMD: 9 genes each for human height and osteoporosis; 4 genes each for human osteoarthritis (OA) and fracture risk; and 2 genes each for adolescent idiopathic scoliosis (AIS), periodontitis, osteosarcoma growth, and tooth development.
|
31646011 |
2019 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Despite normal areal BMD values assessed by dual-energy X-ray absorptiometry and no family history of osteoporosis, the patient demonstrated low lumbar spine trabecular bone score, as well as low peripheral trabecular volumetric BMD and deterioration of trabecular microarchitecture assessed by high-resolution peripheral quantitative computed tomography.
|
31273389 |
2019 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Disease severity (GOLD 3 and 4) was significantly associated with higher risk of vitamin D deficiency (p = 0.032), lower BMD (both men and women at all sites), higher frequency of osteoporosis (in women at all sites), lower skeletal mass index, and higher rate of low lean mass (in both men and women) than healthy controls and COPD patients with milder disease (GOLD 1 and 2).
|
29564475 |
2018 |
|
Osteoporosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Faecal microbiota profiles were determined from 181 individuals with osteopenia (n = 61) or osteoporosis (n = 60), and an age- and gender-matched group with normal BMD (n = 60).
|
31378815 |
2019 |
|
Osteoporosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
FN_BMD is an important risk factor for osteoporosis.
|
30172742 |
2018 |
|
Osteoporosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, specific genetic variants influencing BMD and contributing to the pathogenesis of osteoporosis are largely uncharacterized.
|
21773993 |
2011 |