Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE Certain S100 proteins, namely S100A4, the S100A8/S100A9 heterodimer and S100B, have been implicated in the pathophysiology of obesity-promoting macrophage-based inflammation via toll-like receptor 4 and/or receptor for advanced glycation end-products ligation. 31363816 2020
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE In human and murine adipose tissue, the accumulation of ligands of the receptor for advanced glycation end products (RAGE) accompanies obesity, implicating this receptor in energy metabolism. 31315054 2019
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE While the relationship between RAGE and obesity and inflammation has been well-characterized, few studies describe the effects of phlorotannin on RAGE. 31661887 2019
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE Soluble Receptor for Advanced Glycation End Products and Its Correlation with Vascular Damage in Adolescents with Obesity. 31412337 2019
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE The article suggests the need for the development of an esRAGE/sRAGE targeted pharmacotherapy as a treatment approach for obesity and its comorbidity. 31293451 2019
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE RAGE protein was lower in OB and OB-IR groups; RAGE was located predominantly on the cell-surface in the OB-IR group compared to the HS group (22% vs 9.5%, <i>P</i><0.001). 31231489 2019
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE Association between metabolically healthy central obesity in women and levels of soluble receptor for advanced glycation end products, soluble vascular adhesion protein-1, and the activity of semicarbazide-sensitive amine oxidase. 28409494 2017
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE In the present study, the determination of possible risks in the development of obesity according to RAGE polymorhisms and plasma levels of RAGE (sRAGE) was aimed. 27188863 2016
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE The S allele in RAGE gene is more frequently detected with obesity. 26991258 2016
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE Taken together, these data suggest that although genetically determined to a substantial degree, the sRAGE levels also depend on age and obesity, which in turn, increase the risk for a variety of pathological conditions associated with sRAGE. 25681682 2015
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE In this study, we observed a strong CML accumulation and increased expression of RAGE in adipose tissue in obesity. 24723555 2014
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE The interaction between obesity and RAGE polymorphisms on the risk of knee osteoarthritis in Chinese population. 22987041 2012