Disease: Impaired cognition ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.050 AlteredExpression disease BEFREE RAGE over-expression in the hippocampal vascular endothelial cells possibly resulted in the excessive transport of the plasma Aβ1-40 into the brain after treatment with sevoflurane, which was associated with sevoflurane-induced cognitive dysfunction in aged mice. 31521721 2020
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.050 Biomarker disease BEFREE Targeted inhibition of RAGE reduces amyloid-β influx across the blood-brain barrier and improves cognitive deficits in db/db mice. 29248482 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.050 Biomarker disease BEFREE Here, we investigated the role of the receptor for advanced glycation end products (RAGE) in neuroinflammation, neurodegeneration-associated changes, and cognitive dysfunction arising after sepsis recovery. 29127203 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.050 Biomarker disease BEFREE The present study aimed to determine whether the RAGE-specific antibody protects against BBB disruption and cognitive impairment induced by isoflurane exposure in aged rats. 28115220 2017
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.050 Biomarker disease BEFREE These findings indicated that upregulating RAGE and/or downregulating LRP-1 at the hippocampus and the prefrontal lobe contributed to the Aβ<sub>1-42</sub> accumulation and then further promoted the cognitive impairment of diabetic rats. 28401370 2017