Rheumatoid Arthritis
|
0.230 |
Biomarker
|
disease |
MGD |
|
|
|
Bacterial Infections
|
0.010 |
GeneticVariation
|
group |
BEFREE |
This accumulation of DNA in the DNase II mutants caused the constitutive expression of the antibacterial genes for diptericin and attacin, which are usually activated during bacterial infection.
|
12381665 |
2002 |
Lupus Erythematosus, Systemic
|
0.330 |
Biomarker
|
disease |
BEFREE |
Genetic associations of DNase II with SLE and related phenotypes were examined in Korean patients with SLE.
|
15723160 |
2005 |
Kidney Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
DNase II polymorphisms associated with risk of renal disorder among systemic lupus erythematosus patients.
|
15723160 |
2005 |
Rheumatoid Arthritis
|
0.230 |
GeneticVariation
|
disease |
BEFREE |
Intriguingly, homozygosity for the RA associated DNASE2 -1066 G allele had an additive effect on the disease susceptibility conferred by the wt allele of CCR5 (OR = 2.24, P = 0.0051 for carrier of both RA associated alleles)
|
19538721 |
2009 |
Rheumatoid Arthritis
|
0.230 |
Biomarker
|
disease |
BEFREE |
The association of DNASE2 -1066 GG homozygosity with RA was limited to rheumatoid factor-positive disease, but was not influenced by the presence of anti-cyclic citrullinated peptide or antinuclear antibodies.
|
18812394 |
2009 |
Red Blood Cell Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
|
19862010 |
2009 |
Autoimmune Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
The association of SNPs in the 5'-regulatory region of the DNA degrading enzyme DNASE2 with RA implies a role for this enzyme in the pathogenesis of this autoimmune disease.
|
18812394 |
2009 |
Arthritis, Adjuvant-Induced
|
0.200 |
Biomarker
|
disease |
CTD_mouse |
Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation.
|
20974942 |
2010 |
Splenomegaly
|
0.200 |
Biomarker
|
phenotype |
CTD_mouse |
Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation.
|
20974942 |
2010 |
Arthritis, Collagen-Induced
|
0.200 |
Biomarker
|
disease |
CTD_mouse |
Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation.
|
20974942 |
2010 |
Arthritis, Experimental
|
0.200 |
Biomarker
|
disease |
CTD_mouse |
Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation.
|
20974942 |
2010 |
Anemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
DNase II(-/-) embryos suffer from lethal anemia due to IFN-beta produced in the macrophages carrying undigested DNA.
|
20706988 |
2010 |
Rheumatoid Arthritis
|
0.230 |
AlteredExpression
|
disease |
BEFREE |
Since the three SNPs in the promoter region of the DNase II gene could affect in vivo DNase II activity through reduction of the promoter activity, it is feasible to identify these SNPs susceptible to RA.
|
23019102 |
2012 |
Corpuscular Hemoglobin Concentration Mean
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Seventy-five genetic loci influencing the human red blood cell.
|
23222517 |
2012 |
Autoimmune Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
In addition, if nucleases, such as DNase II or DNase III (Trex1), fail to clear self-DNA, accumulated DNA gains access to intracellular compartments where it drives inflammatory responses leading to autoimmune disease.
|
23417527 |
2013 |
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data suggest that the SNPs in DNL genes may serve as independent prognostic markers for NSCLC patients after surgery.
|
25227797 |
2014 |
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Single nucleotide polymorphisms (SNPs) of DNL genes have been reported to be associated with prognosis of some malignancies.
|
25735330 |
2015 |
Liver carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
However, the effects of SNPs in DNL genes on overall survival of HCC patients receiving transarterial chemoembolization (TACE) treatment are still unknown.
|
25735330 |
2015 |
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
SNPs in DNL genes may serve as independent prognostic markers for HCC patients after surgery.
|
25826294 |
2015 |
Reticulocyte count (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
Autoimmune Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
To continue our previous investigations, we have extensively investigated the function of the 61, 41, and 35 non-synonymous single nucleotide polymorphisms (SNPs) in the human genes encoding DNASE1, DNASE1L3, and DNASE2, respectively, potentially relevant to autoimmune diseases.
|
27116004 |
2016 |
Lupus Erythematosus, Systemic
|
0.330 |
Biomarker
|
disease |
BEFREE |
Most Dnase1 and Dnase2 family members are poorly characterized, yet their elimination can lead to a wide range of diseases, including lethal anemia, parakeratosis, cataracts and systemic lupus erythematosus.
|
28666955 |
2017 |
Lupus Erythematosus, Systemic
|
0.330 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Type I interferon-mediated autoinflammation due to DNase II deficiency.
|
29259162 |
2017 |
Fibrosis, Liver
|
0.320 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Type I interferon-mediated autoinflammation due to DNase II deficiency.
|
29259162 |
2017 |