|
Fibrosis, Liver
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Dnase2<sup>-/-</sup> Ifnar<sup>-/-</sup> mice were shown to recapitulate many features of the DNase II-deficient patients including cytopenia, extramedullary hematopoiesis and liver fibrosis.
|
31464028 |
2020 |
|
Rheumatoid Arthritis
|
0.230 |
GeneticVariation
|
disease |
BEFREE |
Intriguingly, homozygosity for the RA associated DNASE2 -1066 G allele had an additive effect on the disease susceptibility conferred by the wt allele of CCR5 (OR = 2.24, P = 0.0051 for carrier of both RA associated alleles)
|
19538721 |
2009 |
|
Red Blood Cell Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
|
19862010 |
2009 |
|
Reticulocyte count (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Corpuscular Hemoglobin Concentration Mean
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Seventy-five genetic loci influencing the human red blood cell.
|
23222517 |
2012 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Single nucleotide polymorphisms (SNPs) of DNL genes have been reported to be associated with prognosis of some malignancies.
|
25735330 |
2015 |
|
Liver carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
However, the effects of SNPs in DNL genes on overall survival of HCC patients receiving transarterial chemoembolization (TACE) treatment are still unknown.
|
25735330 |
2015 |
|
Bacterial Infections
|
0.010 |
GeneticVariation
|
group |
BEFREE |
This accumulation of DNA in the DNase II mutants caused the constitutive expression of the antibacterial genes for diptericin and attacin, which are usually activated during bacterial infection.
|
12381665 |
2002 |
|
Kidney Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
DNase II polymorphisms associated with risk of renal disorder among systemic lupus erythematosus patients.
|
15723160 |
2005 |
|
Autoinflammatory disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Patients with hypomorphic mutations in DNase II develop a severe and debilitating autoinflammatory disease.
|
31464028 |
2020 |
|
Lupus Erythematosus, Systemic
|
0.330 |
Biomarker
|
disease |
BEFREE |
Most Dnase1 and Dnase2 family members are poorly characterized, yet their elimination can lead to a wide range of diseases, including lethal anemia, parakeratosis, cataracts and systemic lupus erythematosus.
|
28666955 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.330 |
Biomarker
|
disease |
BEFREE |
Genetic associations of DNase II with SLE and related phenotypes were examined in Korean patients with SLE.
|
15723160 |
2005 |
|
Lupus Erythematosus, Systemic
|
0.330 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Type I interferon-mediated autoinflammation due to DNase II deficiency.
|
29259162 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.330 |
Biomarker
|
disease |
BEFREE |
We describe a 17-year-old boy with DNase II deficiency, presenting a clinical picture with significant overlap with systemic lupus erythematosus.
|
31448075 |
2020 |
|
Fibrosis, Liver
|
0.320 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Type I interferon-mediated autoinflammation due to DNase II deficiency.
|
29259162 |
2017 |
|
Glomerulonephritis, Membranoproliferative
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Type I interferon-mediated autoinflammation due to DNase II deficiency.
|
29259162 |
2017 |
|
Autoinflammatory disorder
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Type I interferon-mediated autoinflammation due to DNase II deficiency.
|
29259162 |
2017 |
|
Rheumatoid Arthritis
|
0.230 |
Biomarker
|
disease |
MGD |
|
|
|
|
Rheumatoid Arthritis
|
0.230 |
Biomarker
|
disease |
BEFREE |
The association of DNASE2 -1066 GG homozygosity with RA was limited to rheumatoid factor-positive disease, but was not influenced by the presence of anti-cyclic citrullinated peptide or antinuclear antibodies.
|
18812394 |
2009 |
|
Arthritis, Adjuvant-Induced
|
0.200 |
Biomarker
|
disease |
CTD_mouse |
Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation.
|
20974942 |
2010 |
|
Splenomegaly
|
0.200 |
Biomarker
|
phenotype |
CTD_mouse |
Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation.
|
20974942 |
2010 |
|
Arthritis, Collagen-Induced
|
0.200 |
Biomarker
|
disease |
CTD_mouse |
Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation.
|
20974942 |
2010 |
|
Arthritis, Experimental
|
0.200 |
Biomarker
|
disease |
CTD_mouse |
Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation.
|
20974942 |
2010 |
|
Autoimmune Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
The association of SNPs in the 5'-regulatory region of the DNA degrading enzyme DNASE2 with RA implies a role for this enzyme in the pathogenesis of this autoimmune disease.
|
18812394 |
2009 |
|
Autoimmune Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
In addition, if nucleases, such as DNase II or DNase III (Trex1), fail to clear self-DNA, accumulated DNA gains access to intracellular compartments where it drives inflammatory responses leading to autoimmune disease.
|
23417527 |
2013 |