DNASE2, deoxyribonuclease 2, lysosomal, 1777

N. diseases: 29; N. variants: 6
Disease: Fibrosis, Liver ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.320 GeneticVariation disease BEFREE Dnase2<sup>-/-</sup> Ifnar<sup>-/-</sup> mice were shown to recapitulate many features of the DNase II-deficient patients including cytopenia, extramedullary hematopoiesis and liver fibrosis. 31464028 2020
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.320 AlteredExpression disease BEFREE In fatty livers, DNase II activity is suppressed in contrast to simple inactivation of Bcl-xL or Mcl-1, and both apoptotic and non-apoptotic hepatocyte death can develop, leading to the progression of liver fibrosis. 29855540 2019
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.320 Biomarker disease GENOMICS_ENGLAND Type I interferon-mediated autoinflammation due to DNase II deficiency. 29259162 2017