|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We also found that the DNA methyltransferase 1 (DNMT1) enzyme is highly up-regulated in FGFR1-driven leukemias and lymphomas and that FGFR1 inhibition reduces DNMT1 expression.
|
31628193 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Combination of a hypomethylating agent and inhibitors of PARP and HDAC traps PARP1 and DNMT1 to chromatin, acetylates DNA repair proteins, down-regulates NuRD and induces apoptosis in human leukemia and lymphoma cells.
|
29423093 |
2018 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings reveal the FABP4/DNMT1 axis in the control of AML cell fate in obesity and suggest that interference with the FABP4/DNMT1 axis might be a new strategy to treat leukemia.
|
27885273 |
2017 |
|
leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Our study for the first time demonstrates that DNMT1-dependent DNA methylation mediates the anticancer actions of TQ, opening a window to develop TQ as a novel DNA hypomethylating agent for leukemia therapy.
|
28415607 |
2017 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further investigations of the promoter analysis of CH25H gene and therapeutic effects of DNMT inhibitors on MDS/leukemia will be warranted.
|
26577244 |
2015 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The inhibition of DNMT1 activity impaired the self-renewal and increased expression of PTEN of leukemia initiating cells-enriched fraction.
|
25444908 |
2015 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This work strongly suggests that a direct pharmacological inhibition of DNMT1, unlike the use of 5-aza-2'-deoxycytidine, should lead to tumor suppressor gene hypomethylation and re-expression without inducing major DNA damage in leukemia.
|
25948775 |
2015 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
T-dCyd markedly depleted DNMT1 in CCRF-CEM and KG1a leukemia and NCI-H23 lung carcinoma cell lines, while it was ineffective in the HCT-116 colon or IGROV-1 ovarian tumor lines.
|
24908436 |
2014 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mouse models with conditional knockout of the DNA methyltransferase 1 (DNMT1) and DNA methyltransferase 3A (DNMT3A) genes have revealed a role of DNA methylation in mediating the self-renewal and differentiation of normal hematopoietic stem cells (HSCs) and the leukemia stem cells (LSCs).
|
23507483 |
2013 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Following confirmation of the natural history of this leukemia in the transgenic mice, we demonstrated that the transformed murine lymphocytes express relevant therapeutic targets (Bcl-2, Mcl-1, AKT, PDK1, and DNMT1), wild-type p53 status, and in vitro sensitivity to therapeutic agents relevant to the treatment of human CLL.
|
16670263 |
2006 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine the roles of DNMT3A, DNMT3B, as well as DNMT1, in the development of leukemia, competitive polymerase chain reaction (PCR) assays were performed and the expression levels of DNMTs were measured in normal hematopoiesis, 33 cases of acute myelogenous leukemia (AML), and 17 cases of chronic myelogenous leukemia (CML).
|
11222358 |
2001 |