Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
We show that gallic acid (GA) changes the methylome of lung cancer and pre-malignant oral cell lines and markedly reduces both nuclear and cytoplasmic DNMT1 and DNMT3B within 1 week.
|
29416619 |
2018 |
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
These results indicate that targeting DNMT1 may inhibit tumor metastasis and that DNMT1 is a promising target for the novel treatment of lung cancer.
|
29805653 |
2018 |
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Notably, DNMT1 was downregulated in the LC group and its expression was further reduced in the presence of increasing malignant burden as it was implied by the endobronchial findings.
|
29568927 |
2018 |
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Strategies targeting DNMT1 diminished the <i>IGF2</i> expression and potentiated vorinostat sensitivity in preclinical models of lung cancer with hypermethylation in the <i>H19/IGF2</i> ICR.
|
27582487 |
2017 |
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Here, using human lung cancer tissue microarrays and fresh frozen tissues, we found that the overexpression of DNMT1 is positively correlated with the upregulation of KIT in tumor tissues.
|
28869603 |
2017 |
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
Targeting EP4 downstream c-Jun through ERK1/2-mediated reduction of DNMT1 reveals novel mechanism of solamargine-inhibited growth of lung cancer cells.
|
27620163 |
2017 |
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Importantly, knockdown of DNMT1 by siRNA <i>in vivo</i> also effectively demethylated the RASSF1A and APC promoter, elevated their expressions and limited tumor growth, which functioned like 5-Aza-CR but with alleviated side effects, suggesting that knockdown of DNMT1 might be potential strategy for the treatment of lung cancer with better tolerability.
|
28938637 |
2017 |
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
Identification of DBCCR1 as a suppressor in the development of lung cancer that is associated with increased DNA methyltransferase 1.
|
28427182 |
2017 |
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
These findings identify functional cross-talk between KIT and DNMT1 in the development of drug resistance, implying the reciprocal targeting of protein kinases and DNA methyltransferases as an essential strategy for durable responses in lung cancer.
|
26085088 |
2015 |
Carcinoma of lung
|
0.300 |
Biomarker
|
disease |
BEFREE |
T-dCyd markedly depleted DNMT1 in CCRF-CEM and KG1a leukemia and NCI-H23 lung carcinoma cell lines, while it was ineffective in the HCT-116 colon or IGROV-1 ovarian tumor lines.
|
24908436 |
2014 |
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Finally, immunohistochemistry on human lung cancer specimens revealed a significant increase in DNMT1, HDAC1, HDAC2, and HDAC3 expression, supporting our hypotheses that class I HDACs are mediators of DNMT1 stability.
|
24441677 |
2014 |
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Enforced expression of miRNA-148a in lung cancer cell lines resulted in a significant reduction in the expression of DNMT1.
|
23843100 |
2013 |
Carcinoma of lung
|
0.300 |
ModifyingMutation
|
disease |
RGD |
Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a.
|
21163286 |
2011 |
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer.
|
20570896 |
2010 |
Carcinoma of lung
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
17beta-Estradiol decreased DNMT1 and HDAC1 protein expressions and their binding activity on MGMT promoter, and this may partially contribute to the gender difference of MGMT hypermethylation in lung cancer.
|
19596925 |
2009 |
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In this study, we further speculated that the HPV infection may be linked with the expression of DNA methyltransferase (DNMT) protein in lung cancer patients and it was observed that an association of p16INK4a promoter hypermethylation with HPV infection existed, but only in female cases (P<0.0001).
|
16004934 |
2005 |
Carcinoma of lung
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
To this end, we used RNA interference to specifically down-regulate DNMT1 protein expression in NCI-H1299 lung cancer and HCC1954 breast cancer cells.
|
15126351 |
2004 |