DNMT1, DNA methyltransferase 1, 1786

N. diseases: 496; N. variants: 36
Disease: Mammary Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.360 Biomarker group BEFREE Taken together, these results suggest that DNMTs could be an effective factor in development of tamoxifen resistance in breast tumors. 30359738 2019
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.360 AlteredExpression group BEFREE We demonstrate that breast tumor xenografts in rats exposed to dLAN and circadian MLT disrupted express elevated levels of phosphorylated and acetylated STAT3, increased DNMT1, but reduced sirtuin 1 (SIRT1) and ARHI. 31077613 2019
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.360 Biomarker group BEFREE To evaluate the contribution of DNMTs expression and their promoter methylation as diagnostic biomarkers in development of breast malignancy and tamoxifen resistance, the present study was designed and 107 breast tumors and normal breast tissues were recruited. 29574992 2018
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.360 Biomarker group CTD_human Long non-coding RNA H19 promotes the proliferation and invasion of breast cancer through upregulating DNMT1 expression by sponging miR-152. 28544374 2017
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.360 AlteredExpression group BEFREE Disruption of STAT3-DNMT1 interaction by SH-I-14 induces re-expression of tumor suppressor genes and inhibits growth of triple-negative breast tumor. 29137356 2017
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.360 Biomarker group CTD_human Clinicopathologic significance of DNA methyltransferase 1, 3a, and 3b overexpression in Tunisian breast cancers. 22520950 2012
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.360 Biomarker group LHGDN Inhibition of histone deacetylases promotes ubiquitin-dependent proteasomal degradation of DNA methyltransferase 1 in human breast cancer cells. 18505931 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.360 AlteredExpression group LHGDN Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer. 15755728 2005