DNMT3B, DNA methyltransferase 3 beta, 1789

N. diseases: 315; N. variants: 38
Disease: Malignant tumor of colon ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 Biomarker disease BEFREE Our data identify the MDSC-IL-10-STAT3-DNMT3b-IRF8 pathway as a link between chronic inflammation and colon cancer initiation. 30540937 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 PosttranslationalModification disease BEFREE Importantly, by relieving the repression on DNMT3b, the lower expression of miR-203 in CRC caused ABCG2 promoter methylation and remarkable lower ABCG2 expression in colon cancer cell lines and the patient CRC specimens. 27253631 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression disease BEFREE Furthermore, transduction of miR-339 and miR-766 expressing viruses into colon cancer cell lines (SW480 and HCT116) decreased DNMT3B expression (1.5, 3-fold) and (3, 4-fold), respectively. 27668319 2016
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 GeneticVariation disease BEFREE Our results suggest that DNMT3b polymorphism is involved in the development of colon cancer and non-random genes promoter methylation among Iranian population. 25769449 2015
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 Biomarker disease BEFREE Our results confirm that depletion of DNMT3B specifically reduced the proliferation rate of DNMT3B-overexpressing colon cancer cell lines. 22563479 2012
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression disease BEFREE Our results show a new molecular mechanism of aberrant DNMT3B regulation in colon cancer and suggest that its expression is associated with the methylation of constitutively hypermethylated promoters in the healthy colon. 22244828 2012
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 Biomarker disease BEFREE The purpose of this study was to identify the targets of DNMT3B, an essential DNA methyltransferase in mammals, in colon cancer. 20454457 2010
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 Biomarker disease BEFREE We screened genome wide for novel methylated genes through methylation subtraction of a genetic demethylation model of colon cancer (double knockout of DNMT1 and DNMT3B in HCT116) and identified DLEC1 (Deleted in lung and oesophageal cancer 1), a major 3p22.3 TSG, as one of the methylated targets. 19156137 2009
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression disease BEFREE We hypothesized that cellular DNMT3B level might influence the occurrence of widespread CpG island methylation (i.e., the CpG island methylator phenotype, CIMP) in colon cancer. 19470733 2009
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 PosttranslationalModification disease BEFREE We chose 44 genes coregulated by DNMT3B and PRC1/PRC2 to test whether these criteria would accurately identify novel targets of epigenetic silencing in colon cancer. 19723660 2009
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 GeneticVariation disease BEFREE DNMT3b SNP has been associated with susceptibility to lung, head, neck, and breast cancer, but its association with the development of colon cancer has not been reported. 17318376 2007
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression disease BEFREE Comparing miRNA expression profiles between colon cancer cell line HCT 116 and its derivative, DNA methyltransferase 1 and 3b (DNMT1 and DNMT3b) double knockout cell line, we found that the expression of about 10% miRNAs was regulated by DNA methylation. 17660710 2007