|
Middle East Respiratory Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that the spike (S) proteins of the prototypic Arabian MERS-CoV strain, human betacoronavirus 2c EMC/2012, and the above stated African MERS-CoV variants do not appreciably differ in expression, DPP4 binding and ability to drive entry into target cells.
|
31357164 |
2019 |
|
Middle East Respiratory Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Middle East respiratory syndrome coronavirus (MERS-CoV) uses the S1<sup>B</sup> domain of its spike protein to bind to dipeptidyl peptidase 4 (DPP4), its functional receptor, and its S1<sup>A</sup> domain to bind to sialic acids.
|
31167913 |
2019 |
|
Middle East Respiratory Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
To test the neutralising capacity of these antisera in vivo, susceptibility to MERS-CoV was induced in naive recipient Balb/c mice by the administration of an adenovirus vector expressing the human DPP4 receptor (Ad5-hDPP4) for MERS-CoV, prior to the passive transfer of the RBD-specific murine antisera to the transduced mice.
|
31178378 |
2019 |
|
Middle East Respiratory Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elevated Human Dipeptidyl Peptidase 4 Expression Reduces the Susceptibility of hDPP4 Transgenic Mice to Middle East Respiratory Syndrome Coronavirus Infection and Disease.
|
30256968 |
2019 |
|
Middle East Respiratory Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Most neutralizing antibodies against Middle East respiratory syndrome coronavirus (MERS-CoV) target the receptor-binding domain (RBD) of the spike glycoprotein and block its binding to the cellular receptor dipeptidyl peptidase 4 (DPP4).
|
31296843 |
2019 |
|
Middle East Respiratory Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Co-localization of Middle East respiratory syndrome coronavirus (MERS-CoV) and dipeptidyl peptidase-4 in the respiratory tract and lymphoid tissues of pigs and llamas.
|
30520548 |
2019 |
|
Middle East Respiratory Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previously, we reported the emergence and spread of mutant Middle East respiratory syndrome coronavirus bearing spike mutations (I529T or D510G) with reduced affinity to human receptor CD26 during the outbreak.
|
30900977 |
2019 |
|
Middle East Respiratory Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus.
|
30626685 |
2019 |
|
Middle East Respiratory Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Reduction of soluble dipeptidyl peptidase 4 levels in plasma of patients infected with Middle East respiratory syndrome coronavirus.
|
29587190 |
2018 |
|
Middle East Respiratory Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Receptor Usage of a Novel Bat Lineage C Betacoronavirus Reveals Evolution of Middle East Respiratory Syndrome-Related Coronavirus Spike Proteins for Human Dipeptidyl Peptidase 4 Binding.
|
29346682 |
2018 |
|
Middle East Respiratory Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients.
|
29020176 |
2018 |
|
Middle East Respiratory Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The major mechanism of antibody-mediated neutralization of the Middle East respiratory syndrome coronavirus (MERS-CoV) involves competition with the cellular receptor dipeptidyl peptidase 4 (DPP4) for binding to the receptor-binding domain (RBD) of the spike (S) glycoprotein.
|
29996104 |
2018 |
|
Middle East Respiratory Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The receptor of Middle East respiratory syndrome coronavirus (MERS-CoV) is dipeptidyl peptidase 4 (DPP4).
|
29887526 |
2018 |
|
Middle East Respiratory Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this paper, we will review emerging data on CD26-mediated immune regulation suggesting that CD26 may be an appropriate therapeutic target for the treatment of selected immune disorders as well as Middle East respiratory syndrome coronavirus.
|
29772527 |
2018 |
|
Middle East Respiratory Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous findings of Middle East Respiratory Syndrome coronavirus (MERS-CoV)-related viruses in bats, and the ability of Tylonycteris-BatCoV HKU4 spike protein to utilize MERS-CoV receptor, human dipeptidyl peptidase 4 hDPP4, suggest a bat ancestral origin of MERS-CoV.
|
30531999 |
2018 |
|
Middle East Respiratory Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As mice are restricted to infection at the level of DPP4, the MERS-CoV receptor, we generated mice with humanized exons 10-12 of the mouse <i>Dpp4</i> locus.
|
28348219 |
2017 |
|
Middle East Respiratory Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Permissivity of Dipeptidyl Peptidase 4 Orthologs to Middle East Respiratory Syndrome Coronavirus Is Governed by Glycosylation and Other Complex Determinants.
|
28747502 |
2017 |
|
Middle East Respiratory Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARγ.
|
28118607 |
2017 |
|
Middle East Respiratory Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results show that the spread of MERS-CoV can also be controlled by decreasing the expression rate of DPP4.
|
28894474 |
2017 |
|
Middle East Respiratory Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Middle East respiratory syndrome coronavirus (MERS-CoV) has been shown to infect both humans and dromedary camels using dipeptidyl peptidase-4 (DPP4) as its receptor.
|
28446791 |
2017 |
|
Middle East Respiratory Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
A surface spike (S) protein guides MERS-CoV entry into host cells by binding to cellular receptor dipeptidyl peptidase-4 (DPP4), followed by fusion between virus and host cell membranes.
|
27936982 |
2017 |
|
Middle East Respiratory Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Indeed, several amino acid substitutions were identified in key binding residues that were predicted to block PREDICT/PDF-2180 from attaching to the MERS-CoV DPP4 receptor.
|
28377531 |
2017 |
|
Middle East Respiratory Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It bound strongly to the receptor of MERS-CoV, dipeptidyl peptidase 4 (DPP4), and elicited robust RBD-specific neutralizing antibodies in mice, maintaining long-term neutralizing activity against MERS-CoV infection.
|
27750111 |
2016 |
|
Middle East Respiratory Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mapping the Specific Amino Acid Residues That Make Hamster DPP4 Functional as a Receptor for Middle East Respiratory Syndrome Coronavirus.
|
27030263 |
2016 |
|
Middle East Respiratory Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Spread of Mutant Middle East Respiratory Syndrome Coronavirus with Reduced Affinity to Human CD26 during the South Korean Outbreak.
|
26933050 |
2016 |