|
Amyotrophic Lateral Sclerosis
|
0.470 |
AlteredExpression
|
disease |
BEFREE |
C9-ALS motor neurons showed altered expression of genes involved in membrane excitability including DPP6, and demonstrated a diminished capacity to fire continuous spikes upon depolarization compared to control motor neurons.
|
24154603 |
2013 |
|
Amyotrophic Lateral Sclerosis
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs located in genes that were implicated by previous GWA studies of ALS were marginally significant in the pooled analysis of discovery and replication samples: rs17174381 in DPP6 (p = 4.4×10(-4)) and rs6985069 near ELP3 (p = 4.8×10(-4)).
|
22470424 |
2012 |
|
Amyotrophic Lateral Sclerosis
|
0.470 |
Biomarker
|
disease |
BEFREE |
No association of DPP6 with amyotrophic lateral sclerosis in an Italian population.
|
19525032 |
2011 |
|
Amyotrophic Lateral Sclerosis
|
0.470 |
Biomarker
|
disease |
BEFREE |
Analysis of DPP6 and FGGY as candidate genes for amyotrophic lateral sclerosis.
|
20001489 |
2010 |
|
Amyotrophic Lateral Sclerosis
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
In our association analyses, we identified two loci that met our criteria for follow-up: the DPP6 locus (OR = 3.59, P = 6.6 × 10(-3)), which has already been implicated in ALS pathogenesis, and the 15q11.2 locus, containing NIPA1 (OR = 12.46, P = 9.3 × 10(-5)), the gene causing hereditary spastic paraparesis type 6 (HSP 6).
|
20685689 |
2010 |
|
Amyotrophic Lateral Sclerosis
|
0.470 |
Biomarker
|
disease |
BEFREE |
Indeed, the three loci (FGGY, ITPR2 and DPP6) identified in previous GWAS of sporadic ALS were not significantly associated with disease in our study.
|
19193627 |
2009 |
|
Amyotrophic Lateral Sclerosis
|
0.470 |
GeneticVariation
|
disease |
GWASDB |
We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43).
|
18084291 |
2008 |
|
Amyotrophic Lateral Sclerosis
|
0.470 |
GeneticVariation
|
disease |
LHGDN |
We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43).
|
18084291 |
2008 |
|
Amyotrophic Lateral Sclerosis
|
0.470 |
GeneticVariation
|
disease |
GWASCAT |
We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43).
|
18084291 |
2008 |
|
Amyotrophic Lateral Sclerosis
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.
|
18084291 |
2008 |
|
Amyotrophic Lateral Sclerosis
|
0.470 |
Biomarker
|
disease |
CTD_human |
We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43).
|
18084291 |
2008 |