DPYD, dihydropyrimidine dehydrogenase, 1806

N. diseases: 249; N. variants: 101
Disease: Carcinoma of lung ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 AlteredExpression disease BEFREE Here we analyzed the relationship between TS and DPD expression and clinicopathological features of lung cancer. 28835573 2017
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 AlteredExpression disease BEFREE However, the role of TS, DPD and OPRT expression in lung cancer has not been fully established. 19288006 2009
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 AlteredExpression disease BEFREE In vitro sensitivity to platinum-derived drugs is associated with expression of thymidylate synthase and dihydropyrimidine dehydrogenase in human lung cancer. 16685392 2006
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 AlteredExpression disease BEFREE Therefore, the expression levels of TS and DPD genes may be useful indicators of 5-FU activity in lung cancer. 15993511 2005
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.050 AlteredExpression disease BEFREE Moreover, breast cancer was characterized by high TS activity and lung cancer by high DPD activity as compared with gastric and colon cancers, and their high activity levels may influence to the effectiveness of 5-fluorouracil against cancers of these organs. 14612954 2003