|
Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study examines the involvement of phosphorylated (p-) CRMP2 and WAVE1 in p-tau aggregates using a triple-transgenic (3×Tg; APPswe/PS1M146V/tauP301L) AD mouse model.
|
26400044 |
2016 |
|
Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, CRMP2 may be involved in vitamin D-mediated memory improvement in AD.
|
31838171 |
2020 |
|
Alzheimer's Disease
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Collectively, our results demonstrate for the first time that OA can induce phosphorylation of CRMP-2 in SK-N-SH cells at sites aberrantly phosphorylated in AD brain, and both GSK-3alpha and 3beta and Ser-522 kinase(s) are involved in this process.
|
17902168 |
2008 |
|
Alzheimer's Disease, Focal Onset
|
0.300 |
Biomarker
|
disease |
CTD_human |
Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD.
|
19374891 |
2009 |
|
Amyloidosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The knockdown of CRMP2 blocked the rescue of aFGF14-154 with broken neurites and shrunken cell bodies in neurons with Aβ injury.
|
31561361 |
2019 |
|
Amyloidosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Diverse cellular subsystems were involved in the penumbra tissue response: signal transduction pathways such as protein kinase Bα/GSK-3, protein kinase C and its β1 and β2 isoforms, Wnt/β-catenin (axin1, GSK-3, FRAT1), Notch/NUMB, DYRK1A, TDP43; mitochondria quality control (Pink1, parkin, HtrA2); ubiquitin-mediated proteolysis (ubiquilin-1, UCHL1); axon outgrowth and guidance (NAV-3, CRMP2, PKCβ2); vesicular trafficking (syntaxin-8, TMP21, Munc-18-3, synip, ALS2, VILIP1, syntaxin, synaptophysin, synaptotagmin); biosynthesis of neuromediators (tryptophan hydroxylase, monoamine oxidase B, glutamate decarboxylase, tyrosine hydroxylase, DOPA decarboxylase, dopamine transporter); intercellular interactions (N-cadherin, PMP22); cytoskeleton (neurofilament 68, neurofilament-M, doublecortin); and other proteins (LRP1, prion protein, β-amyloid).
|
27324898 |
2017 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
These results suggest that the phosphorylation of CRMP2 may contribute to the axonal degeneration of motor neurons in ALS.
|
30194029 |
2019 |
|
Anxiety
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Lacosamide significantly reduced the expression of ethanol-induced CPP and alleviated the levels of hippocampal CRMP-2 but aggravated withdrawal-associated anxiety and depression in mice.
|
31377562 |
2019 |
|
Anxiety Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Lacosamide significantly reduced the expression of ethanol-induced CPP and alleviated the levels of hippocampal CRMP-2 but aggravated withdrawal-associated anxiety and depression in mice.
|
31377562 |
2019 |
|
Autistic Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Of those the STMN4 and DPYSL2 genes are the most likely candidate genes to be involved in neuronal development, and, if altered in gene-dosage, in the autistic phenotype of our patient.
|
18696223 |
2009 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate that GSK3β and its substrate CRMP2 critically regulate the neurite structure of MSNs and their functions specifically within the indirect pathway of the basal ganglia network play a critical role in manifesting mania-like behavior of BD.
|
30699850 |
2019 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans.
|
12951196 |
2003 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans.
|
12951196 |
2003 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
We have previously demonstrated that the DRP-2 gene is associated with susceptibility to schizophrenia, but not to bipolar disorders.
|
17105906 |
2006 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Various other protein products of genes associated with bipolar disorder either bind to or are affected by phosphatidyl-inositol phosphate products of this pathway (ADBRK2, HIP1R, KCNQ2, RGS4, WFS1), are associated with its constituent elements (BCR, DUSP6, FAT, GNAZ) or are downstream targets of this signalling cascade (DPYSL2, DRD3, GAD1, G6PD, GCH1, KCNQ2, NOS3, SLC6A3, SLC6A4, SST, TH, TIMELESS).
|
17239488 |
2007 |
|
Bipolar Disorder
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
We have previously demonstrated that the DRP-2 gene is associated with susceptibility to schizophrenia, but not to bipolar disorders.
|
17105906 |
2006 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Borderline Personality Disorder
|
0.020 |
Biomarker
|
disease |
BEFREE |
The "set-point" for the ratio of pCRMP2:CRMP2 is elevated uniquely in hiPSC-derived neurons from LiR BPD patients, but not with other psychiatric (including lithium-nonresponsive BPD) and neurological disorders.
|
28500272 |
2017 |
|
Borderline Personality Disorder
|
0.020 |
Biomarker
|
disease |
BEFREE |
The present study did not provide any evidence for a contribution of the DRP-2 gene to susceptibility to BPD.
|
12951196 |
2003 |
|
Brain Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Alterations in CRMP-2 expression that lead to its functional changes are implicated in brain disorders such as epilepsy.
|
28966575 |
2017 |
|
Brain Ischemia
|
0.200 |
Biomarker
|
disease |
RGD |
Upregulation of Dpysl2 and Spna2 gene expression in the rat brain after ischemic stroke.
|
19524114 |
2009 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Phosphorylated CRMP2 was observed in the nuclei of breast cancer cells but not in normal mammary cells (P < 0.001).
|
23381229 |
2014 |
|
Bronchopulmonary Dysplasia
|
0.020 |
Biomarker
|
disease |
BEFREE |
The "set-point" for the ratio of pCRMP2:CRMP2 is elevated uniquely in hiPSC-derived neurons from LiR BPD patients, but not with other psychiatric (including lithium-nonresponsive BPD) and neurological disorders.
|
28500272 |
2017 |
|
Bronchopulmonary Dysplasia
|
0.020 |
Biomarker
|
disease |
BEFREE |
The present study did not provide any evidence for a contribution of the DRP-2 gene to susceptibility to BPD.
|
12951196 |
2003 |