DPYSL2, dihydropyrimidinase like 2, 1808

N. diseases: 93; N. variants: 6
Disease: Schizophrenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 Biomarker disease BEFREE We have identified a list of proteins with significant, >2-fold change in abundance following our manipulations, of which PARK7/DJ-1 - an anti-oxidant implicated in hereditary forms of Parkinson's Disease (PD), and DPYSL2/CRMP-2 - a microtubule-binding phosphoprotein involved in schizophrenia pathogenesis - were both found to have measurable effects on neuronal homeostasis and phenotype. 30562574 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 Biomarker disease BEFREE Our results support the functional importance of the DPYSL2 DNR and a role for mTOR signaling in schizophrenia. 27801893 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 Biomarker disease BEFREE Taken together with previous studies investigating the association between the DPYSL2 gene and schizophrenia, the present findings may contribute additional evidence regarding developmental theories of the pathophysiology of schizophrenia. 25847191 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 AlteredExpression disease BEFREE The DPYSL2 gene at 8p22-p21 is expressed widely in neuronal tissues and has been implicated in multiple psychiatric disorders such as Alzheimer's disease and schizophrenia. 23846846 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 AlteredExpression disease BEFREE Further, several independent gene expression studies have shown that DPYSL2 is differentially expressed in SZ brains [Beasley et al.2006. 21302347 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 Biomarker disease BEFREE We conclude that DPYSL2 does not have a major function in SCZ in Japanese subjects. 20414250 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 AlteredExpression disease LHGDN Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia. 19110265 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 GeneticVariation disease BEFREE We have previously demonstrated that the DRP-2 gene is associated with susceptibility to schizophrenia, but not to bipolar disorders. 17105906 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 Biomarker disease BEFREE Case-control and TDT analyses were performed to detect association of DPYSL2 with schizophrenia. 16321170 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 GeneticVariation disease LHGDN We conclude that the DRP-2 *2236 C allele may mark another polymorphism in DRP-2, or in a nearby gene, that may influence susceptibility to schizophrenia. 15858820 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 GeneticVariation disease BEFREE We conclude that the DRP-2 *2236 C allele may mark another polymorphism in DRP-2, or in a nearby gene, that may influence susceptibility to schizophrenia. 15858820 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 GeneticVariation disease BEFREE Recently, we demonstrated a significant association between the DRP-2 gene and schizophrenia. 12951196 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 GeneticVariation disease BEFREE Our results suggest that the *2236C allele in the 3'UTR of the DRP-2 gene, or an unknown mutation in linkage disequilibrium with this allele, may reduce the susceptibility to schizophrenia, especially the paranoid subtype. 12679234 2003